金纳多联合巴曲酶对SHL患者氧化应激、血流动力学及凝血功能的影响  

Effects of Ginaton combined with batroxobin on oxidative stress,hemodynamics and coagulation in SHL patients

作　　者：赵艳[1] 赖世佳[1] 艾如涛 黄建明[2] 

机构地区：[1]中国人民解放军第一七四医院体检中心,福建厦门361003 [2]中国人民解放军第一七四医院骨一科,福建厦门361003

出　　处：《海南医学院学报》2017年第21期3028-3031,共4页Journal of Hainan Medical University

基　　金：南京军区医学创新重点项目(12Z21)~~

摘　　要：目的:探讨金纳多联合巴曲酶对突发性耳聋(SHL)患者氧化应激、血流动力学及凝血功能的影响。方法:将100例突发性耳聋患者依据随机数字表法分为对照组和观察组(均50例),对照组患者给予巴曲酶治疗,观察组患者接受金纳多联合巴曲酶治疗。比较治疗前后两组患者氧化应激、血流动力学及凝血功能变化。结果:治疗前,两组患者WBV、HCT、PV、APTT、PT、TT、PF、SOD、LPO水平比较,差异无统计学意义(P>0.05)。治疗后对照组与观察组WBV、PV水平分别为(5.33±0.62)mPaos、(1.73±0.59)mPaos和(4.07±0.55)mPaos、(1.32±0.41)mPaos,两组WBV、PV水平较治疗前均明显降低,且治疗后观察组明显低于对照组(均P<0.05);治疗后对照组与观察组APTT、PT、TT、PF水平分别为(43.75±6.15)s、(18.23±2.02)s、(15.38±2.51)s、(58.61±12.96)μg/L和(53.68±7.16)s、(24.67±4.35)s、(22.51±4.85)s、(41.47±8.63)μg/L,两组APTT、PT、TT水平较治疗前均明显升高,PF明显降低,且治疗后对比观察组PF水平明显低于对照组,APTT、TT、PT水平明显高于对照组(均P<0.05);治疗后对照组与观察组SOD、LPO水平分别为(101.78±10.53)nu/L、(5.91±0.95)mmol/L和(110.07±12.62)nu/L、(4.68±1.02)mmol/L,两组LPO水平较治疗前均明显降低,SOD水平明显升高,且治疗后观察组LPO水平明显低于对照组,SOD水平明显高于对照组(均P<0.05)。结论:与单独使用巴曲酶相比,金纳多联合巴曲酶能够更好的降低突发性耳聋患者应激反应、改善患者血流动力学、凝血功能,值得临床大力推广。Objective:To investigate the effects of ginaton combined with batroxobin on oxidative stress,hemodynamics and coagulation in patients with sudden hearing loss.Methods:According to random data table method,100 cases of sudden hearing loss were randomly divided into the control group(n=50)and observation group(n=50),patients in the control group were given batroxobin treatment,the observation group received ginaton combined with batroxobin theraphy.The levels of oxidative stress,hemodynamics and coagulation were compared between the two groups before and after treatment.Results:The levels of WBV,HCT,PV,APTT,PT,TT,PF,SOD,LPO in the two groups before treatment were not statistically significant(P>0.05).After treatment,the levels of WBV,PV in the control group and observation group were respectively(5.33±0.62)mPaos,(1.73±0.59)mPaosand(4.07±0.55)mPaos,(1.32±0.41)mPaos,which were significantly lower than those before treatment(P<0.05),and after treatment in the observation group the levels of WBV,PV were significantly lower than the control group(P<0.05);After treatment,the levels of APTT,PT,TT,PF in the control group and observation group were respectively(43.75±6.15)s,(18.23±2.02)s,(15.38±2.51)s,(58.61±12.96)μg/L and(53.68±7.16)s,(24.67±4.35)s,(22.51±4.85)s,(41.47±8.63)μg/L,compared with those in the same group before treatment,the levels of APTT,PT and TT were significantly increased(P<0.05),PF level was significantly decreased(P<0.05),and in the observation group APTT,PT and TT levels were significantly higher and PF level was significantly lower than that in the control group(all P<0.05).After treatment,the levels of SOD,LPO in the control group and observation group were respectively(101.78±10.53)nu/L,(5.91±0.95)mmol/L and(110.07±12.62)nu/L,(4.68±1.02)mmol/L compared with those in the same group before treatment,the level of SOD were significantly increased(P<0.05),the level of LPO level was significantly decreased(P<0.05),and in the observation group LPO level was significantly lower and SOD lev

关 键 词：金纳多 巴曲酶 突发性耳聋 氧化应激 血流动力学 凝血功能 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]