采用实际体重或理想体重代入Cockcroft-Gault公式计算肌酐清除率准确性的比较  

Accuracy comparison of creatinine clearance rate predicted by Cockcroft-Gault formula with the actual body weight or the ideal body weight

作　　者：周陶然[1] 

机构地区：[1]同济大学附属同济医院药剂科,上海200065

出　　处：《药学服务与研究》2017年第6期410-410,418,436,共3页Pharmaceutical Care and Research

摘　　要：目的:探讨用Cockcroft-Gault(C-G)公式计算肌酐清除率(creatinine clearance rate,Ccr)时采用实际体重更准确还是理想体重更准确。方法:纳入上海市同济医院肾内科51例病人的临床数据,分别采用实际体重和理想体重代入C-G公式计算肌酐清除率(Ccr_a,Ccr_i),将Ccr与用MDRD公式计算并用体表面积校正所得的肾小球滤过率(glomerular filtration rate,GFR)做相关性分析,比较Ccr_a-GFR的相关系数(ra)和Ccr_i-GFR的相关系数(r_i)的优劣,并按不同体重指数(BMI)做分层比较。结果:体重正常者,ra更接近1;超重者和肥胖者,r_i更接近1。结论:正常体重者适宜采用实际体重,超重及肥胖者适宜采用理想体重。Objective：To study the accuracy of creatinine clearance rate（Ccr）predicted by Cockcroft-Gault（C-G）formula with the actual body weight or the ideal body weight.Methods：The clinical data of 51 patients hospitalized in the Department of Nephrology of Shanghai Tongji Hospital were included in the study.Creatinine clearance rates（Ccra,Ccr_i）were predicted by C-G formula with the actual body weight or the ideal body weight.The correlation between the Ccrs and glomerular filtration rate（GFR）predicted by MDRD formula and corrected by body surface area was analyzed.The correlation coefficient of CcraGFR（ra） and Ccr_i-GFR（r_i） was compared.Stratified compar_isons were made according to the body mass index（BMI）.Results：In the patients with normal body weight,ra was closer to 1,and in overweight and obese patients,r_i was closer to 1.Conclusion：In the patients with normal body weight,the Ccr predicted by C-G formula with the actual body weight was better.However,in those with overweight and obese,the Ccr predicted by C-G formula with the ideal body weight was better.

关 键 词：COCKCROFT-GAULT公式 实际体重 理想体重 肌酐清除率 肾小球滤过率 

分 类 号：R965[医药卫生—药理学] R311[医药卫生—药学]