卡维地洛和美托洛尔治疗老年慢性心力衰竭的效果分析  

Effect analysis for the treatment of senile chronic heart failure with carvedilol and metoprolol

作　　者：萧丽军[1] 洪梅[1] 赵文雪[1] 蒯琳[1] 李华平[1] 陈明月 

机构地区：[1]南京医科大学第二附属医院东院老年科,南京210003

出　　处：《检验医学与临床》2017年第24期3588-3589,3592,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨卡维地洛与美托洛尔对老年慢性心力衰竭的治疗作用。方法选取2014年1月至2016年1月在该院治疗的慢性心力衰竭患者68例作为研究对象,按照随机数字表法分为对照组和观察组,每组各34例。两组患者入院后均行常规基础治疗,对照组口服美托洛尔,观察组口服卡维地洛。比较两组患者的临床效果。结果观察组治疗总有效率为79.41%,高于对照组的55.88%,两组差异有统计学意义(P<0.05);与对照组比较,观察组左心室射血分数相对较高,左心室收缩末期内径和左心室舒张末期内径相对较低,差异均有统计学意义(P<0.05);观察组血清脑钠肽水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论在对老年慢性心力衰竭患者进行治疗时,卡维地洛与美托洛尔均有疗效,但相对而言,卡维地洛的临床优势更明显,值得临床进一步推广应用。Objective To probe effect for the treatment of senile chronic heart failure with carvedilol and metoprolol.Methods68 cases of patients with chronic heart failure,received treatement in the hospital between January 2014 and January 2016,were chosen According to random number table method,the patients were divided into the control group and the observation group,with34 cases each.Both groups of patients were received conventional basic treatment after admission.The control group took oral metoprolol treatment,observation group took oral carvedilol treatment.The clinical effects in two groups were compared.Results After the treatment,the total effective rate of the observation group treatment was 79.41%,which was higher than that of control group55.88%,and the difference was statistically significant(P<0.05).Compared with the control group,the left ventricular ejection fraction of the observation group was relatively high,and left ventricular end systolic diameter(LVESd)and left ventricular end-diastolic diameter was relatively low,and the differences were statistically significant(P<0.05).The serum BNP level of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Incidences of adverse reactions in the two groups had no statistically significant difference.Conclusion In the treatment of elderly patients with chronic heart failure,carvedilol and metoprolol both have curative effect.But the clinical effect of carvedilol was more obvious which is worthy of further popularization and application in clinic.

关 键 词：慢性心力衰竭 卡维地洛 美托洛尔 疗效 

分 类 号：R541.605[医药卫生—心血管疾病]