蔓性千斤拔的化学成分研究  

Chemical constituents of the roots of Moghania philippinensis

作　　者：李帅霖 孙琳[1] 富艳彬[1] 李达翃[1] 李占林[1] 华会明[1,2] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《中国药物化学杂志》2017年第6期462-465,共4页Chinese Journal of Medicinal Chemistry

摘　　要：目的研究蔓性千斤拔(Moghania philippinensis)根的95%(体积分数)乙醇提取物的化学成分。方法采用制备薄层色谱、反复硅胶柱色谱、Sephadex LH-20柱色谱、开放ODS柱色谱等方法进行分离纯化;根据理化性质及波谱分析鉴定化合物的结构。结果与结论从蔓性千斤拔中分离得到9个已知化合物,分别鉴定为大豆素(1)、染料木素(2)、3'-O-methylorobol(3)、2'-羟基染料木素(4)、aureol(5)、lupinalbin A(6)、山柰酚(7)、questin(8)、羽扇豆醇(9)。化合物7、8为首次从该属植物中分离得到,化合物5为首次从该植物中分离得到。To isolate and identify the chemical constituents of the 95% EtOH extract of the roots of Moghania philippinensis, compounds were isolated by various kinds of column chromatography on silica gel, Sephadex LH-20 and ODS. Nine compounds were obtained and their structures were identified as daidzein （ 1 ）, genistein （2）, 3 ＇-O-methylorobol （ 3 ）, 2＇-hydroxygenistein （ 4 ）, aureol （ 5 ）, lupinalbin A （ 6 ）, kaempferol （7）, questin （8）, and lupeol （9） by the physico-chemical characters and spectroscopic analysis, respectively. Compounds 7 and 8 are isolated from Moghania genus for the first time, and compound 5 is isolated from Moghania philippinensis for the first time.

关 键 词：蔓性千斤拔 化学成分 结构鉴定 黄酮类 

分 类 号：R284.1[医药卫生—中药学]