乙肝病毒感染后肾小球肾炎的病理变化  

PATHOLOGICAL CHANGES IN HEPATITIS B VIRUS ASSOCIATED GLOMERULONEPHRITIS

作　　者：任青[1] 冯江敏[2] 周希静[2] 杨玉秀[2] 王丽琛[2] 

机构地区：[1]中国医科大学附属第一医院肾病研究室 [2]中国医科大学附属第一医院肾内科

出　　处：《中国医科大学学报》1991年第5期369-371,共3页Journal of China Medical University

摘　　要：本文对肾小球内有HBsAg沉积的27例各型肾炎的肾组织进行病理分析,其中膜性肾炎8例,膜增殖性肾炎3例,系膜增殖性肾炎13例,局灶硬化性肾炎3例,在各种病理类型的肾炎肾小球中都有不同程度的IgG、IgA、IgM、C_3呈粗大颗粒状沉积,以IgG的荧光强度最大,其轻链以K链为主。通过对沉积在肾小球内凝血纤溶因子的测定,证实其中11例存在高凝状态。透射电镜观察到部分病例肾小球的上皮下、内皮下系膜区有直径在30 nm～70 nm的病毒颗粒。The pathological changes of 27 cases with hepatitis B virus-associatedglomerulonephritis were analysed. There were four types of glomerulonephritis.Immunofluorescent staining showed a massive granular deposits consisting ofIgG, IgA, IgM, C3 and the intensity varied in degrees with various types ofglomerulonephritis. The IgG was the most intensive one. The main lightchain of IgG was K ohain. The hyperccagulable states in 11 specimens wereobserved by detection of coagulation and fibrinolysis factors depcsits inglomeruli. Ultrastructurally, there were finely granular electron-dense depcsitsin the subendothelial area, basement membrane mesangial area, and thesubepithelial area of the glomerular tufts. In some cases, virus-like particlesbetween 30 and 70 nm in diameter were also found in such areas of theglomerular tufts.

关 键 词：乙型肝炎病毒 肾小球肾炎 病理 

分 类 号：R692.310.2[医药卫生—泌尿科学]