呼吸道变应性疾病患儿血清维生素D水平及与IgE抗体的相关性  

Vitamin D level and the correlation with IgE in children with allergic respiratory diseases

作　　者：罗文婷[1] 孙宝清[1] 韦妮莉[1] 梁雪清[1] 黄惠敏[1] 

机构地区：[1]广州医科大学附属第一医院广州呼吸健康研究院呼吸疾病国家重点实验室国家呼吸疾病临床医学研究中心广州医科大学,510120

出　　处：《国际呼吸杂志》2017年第23期1799-1803,共5页International Journal of Respiration

基　　金：国家自然科学基金项目（81572063）;广州市市属高校科研青年项目（1201630044、1201630393）;广州市医药卫生科技项目（20151A011071、20151A010094）;广东省科技厅产学研项目（20138090500129）;广东省科技厅项目（2014A020212352）

摘　　要：目的探讨呼吸道变应性疾病患儿维生素D水平及其与IgE抗体浓度的相关性。方法收集呼吸道变应性疾病患儿70例，年龄从4个月～14岁，用酶联免疫捕获法ALLERG-O—LIQ系统检测血清tIgE和屋尘螨slgE抗体，并采用电化学发光法检测患儿血清维生素D水平。所有数据采用统计学软件SPSS19．0进行处理。结果患儿平均维生素D水平为（33．8±10．3）μg／L。不同性别间维生素D水平差异无统计学意义。不同呼吸道变应性疾病患儿血清维生素D水平分布各异，哮喘合并变应性鼻炎患儿血清维生素D的水平最低，为（28．6±7．6）Ng／L，喘息性支气管炎患儿血清维生素D的水平最高，为（38．8±6．1）μg／L。哮喘合并变应性鼻炎患儿血清维生素D的水平低于喘息性支气管炎患儿，变应性鼻炎患儿血清维生素D水平低于哮喘、咳嗽变异性哮喘和喘息性支气管炎患儿，以上差异均有统计学意义（P〈O．05）。维生素D水平与年龄、tIgE和屋尘螨sIgE抗体浓度呈负相关（rs=0．548，P=0．000；rs==0．397，P=0．001；rs=-0．259，P=0．030）。维生素D不足组平均年龄、tIgE以及屋尘螨sIgE水平均高于维生素D充足组，差异有统计学意义（P〈0．05）。结论维生素D水平可能与呼吸道变应性疾病的发展风险增加有关，呼吸道变应性疾病患儿应注意维生素D的水平变化及补充。Objective To explore the vitamin D （VitD） level and analyse the correlation with immunoglobulin E （IgE） concentration in children with allergic respiratory diseases. Methods Selected 70 children with allergic respiratory diseases, from 4 months to 14 years old. Used capture ELISA ALLERG- O-LIQ assay to detect the serum tlgE and Dermatophagoides pteronyssinus （Dp） sIgE. Used Elecsys to detect the VitD concentration. Data was processed by statistical software SPSS 19.0. Results The average concentration of VitD was （33.8±10.3） μg/L. There was no significant different of VitD concentration between sex. The distribution was varied in different allergic respiratory diseases. The level of VitD in children with asthma combined with rhinitis [（28.6± 7.6） μg/L] was the lowest. The level of VitD in children with asthmatic bronchitis [（38.8 ±6.1）μg/L] was the highest, The level of VitD in children with asthma eomhined with rhinitis was lower than the children with asthmatic bronchitis, the level of VitD in children with allergic rhinitis was lower than the children with asthma, cough variant asthma and asthmatic bronchitis （ P 〈0.05, respectively）. Age, AgE and Dp sIgE were negatively correlated with VitD （rs=-0.548, P =0.000;rs=-0.397, P =0.001;rs=-0.259, P =0.030）.The age, tIgE and Dp sIgE level of VitD insufficent group were higher than the VitD sufficent group（ P 〈0.05）. Conclusions Serum VitD level could be associated with an increased risk of the development of allergic respiratory diseases. The children with allergic respiratory diseases should pay attention to the change of VitD level and supplement.

关 键 词：呼吸道变应性疾病 维生素D IGE抗体 相关性分析 

分 类 号：R725.6[医药卫生—儿科]