MIF、COX-2在子宫内膜异位症中的表达及相关性研究  

Expression and significance of MIF and COX-2 in endometriosis

作　　者：闫文杰[1] 皮洁[1] 杨菁[1] 

机构地区：[1]武汉大学人民医院生殖医学中心,武汉430060

出　　处：《中国性科学》2017年第12期34-37,共4页Chinese Journal of Human Sexuality

基　　金：中央高校基本科研业务费专项资金青年教师资助项目(2042017kf0073)

摘　　要：目的:探讨MIF、COX-2与子宫内膜异位症(endometriosis,EM)的相关性研究。方法:采用免疫组织化学的方法测定EM患者49例异位内膜、40例在位的内膜及对照组正常内膜40例中MIF、COX-2的表达,并进行相关性分析。结果:(1)MIF、COX-2在EM在位内膜、异位内膜的表达率明显高于正常对照组,比较有统计学意义(P<0.01)。(2)异位和在位的内膜组中,MIF、COX-2表达在Ⅲ~Ⅳ期均高于Ⅰ~Ⅱ期,比较有统计学的意义(P<0.05)。(3)异位和在位的内膜组中,MIF表达与COX-2的表达呈正相关性(P<0.05)。结论:MIF可能通过增加COX-2表达而促进EM的发生、发展。Objectives： To study the expression of MIF and COX-2 in endometriosis（ EM） and the correlation between MIF,COX-2 and EM. Methods： MIF and COX-2 expression was detected by immunohistochemistry methods in 40 cases of eutopic endometrium and 49 cases of ectopic endometrium and 40 cases of normal endometium. The results were analyzed statistically. Results：（ 1） The positive expression rate MIF and COX-2 in eutopic and ectopic endometrium were much higher than those in control group（ P 0. 01）.（ 2） In the stage III/IV,the expression of MIF and COX-2 in eutopic and ectopic endometrium were much higher than these in stage I/II（ P 0. 05）.（ 3） The expression of MIF was shown to be significantly correlated to COX-2（ P 0. 01）.Conclusion： The expression of MIF is significantly correlated to the expression of COX-2 in ectopic and eutopic endometriosis,which may play a crucial role in the pathogenesis on endometriosis.

关 键 词：子宫内膜异位症 巨噬细胞移动抑制因子 环氧化酶-2 

分 类 号：R711.71[医药卫生—妇产科学]