维参锌胶囊治疗男性特发性弱精子症的疗效和安全性观察  

Efficacy and safety of Weishenxin capsules on male idiopathic asthenospermia

作　　者：彭靖[1] 张志超[1] 崔万寿[1] 袁亦铭[1] 高冰[1] 

机构地区：[1]北京大学第一医院男科中心,北京100034

出　　处：《中国性科学》2017年第12期85-88,共4页Chinese Journal of Human Sexuality

摘　　要：目的:观察维参锌胶囊治疗男性特发性少弱精子症的疗效和安全性。方法:在2016年1月至8月之间,共筛查64例患者,其中34例患者符合入组条件,平均年龄(31.09±4.18)岁。34例符合入选标准的特发性少精子症或弱精子症患者服用维参锌胶囊单一药物进行治疗3个月,每月复查1次精液常规,比较精液常规的变化和记录不良反应情况。结果:29例患者得到随访,维参锌治疗1个月后69%的患者精液参数较基线有显著改善,精子前向活力(a+b级)显著改善(P<0.05);治疗3个月后精子前向活力较基线和1个月时均有显著改善,分别为(39.07±20.27)、(25.07±11.88)和(35.87±17.56),P<0.05,精子密度没有显著改善。治疗期间的配偶自然怀孕率为17.2%(5/29)。结论:维参锌可以显著而持续的改善精子活力。Objectives： To evaluate the efficacy and safety of Weishenxin capsule on male idiopathic asthenospermia. Methods： 64 patients from January 2016 to August 2016 were selected. 34 patients meeting all inclusion criteria were screened and included in this study with the mean age of 31. 09 ± 4. 18 years old. Patients with asthenospermia（ abnormal semen parameters） were administrated single Weishenxin capsule for 3 months and their semen samples were tested once a month. Semen parameters were compared before and after treatment and side effects were recorded. Results： 29 patients（ 85. 3%） were followed up. The semen parameters were significantly improved in 69% of patients after a month treatment. Sperm forward motility after 3 months＇ treatment were significantly higher than that after a month＇s treatment and baseline（ 39. 07 ± 20. 27,25. 07 ± 11. 88 and 35. 87 ± 17. 56,respectively）. However,the sperm density was not significantly improved after 3 months＇ treatment. 5 patients（ 17.2%） achieved natural pregnancy during the treatment. No side effect was reported. Conclusion： Weishenxin capsules is safe and effective in the treatment of male idiopathic asthenospermia,which can significantly and continuously improve sperm motility.

关 键 词：男性不育症 特发性少弱精子症 维生素E 锌剂 精子活力 

分 类 号：R698.2[医药卫生—泌尿科学]