槲皮素对实验性高尿酸血症疗效的Meta分析  

Therapeutic efficacy of quercetin on experimental hyperuricemia:a meta-analysis

作　　者：卢琪超 陈玲[1] 熊欣荣[1] 彭雪荣 Lu Qichao;Chen Ling;Xiong Xinrong;et al.(Department of Nephrology, Fengcheng People＇s Hospital, Yichun 331100)

机构地区：[1]丰城市人民医院,江西宜春331100

出　　处：《中国现代医药杂志》2017年第12期49-54,共6页Modern Medicine Journal of China

摘　　要：目的系统评价槲皮素治疗实验性高尿酸血症的疗效。方法计算机检索Pubmed、Medline、Embase、The Cochrane library、万方、维普、中国知网以及Google Scholar,查找有关槲皮素治疗实验性高尿酸血症的随机对照试验,在严格质量评估的基础上,使用Stata12.0软件进行Meta分析。结果共筛选出7个随机对照试验(RCTs),共187只实验动物,文献质量评分8分1篇,7分4篇,5分2篇。Meta分析结果:观察组与对照组的血清尿酸[SMD=-1.708,95%CI(-2.000,-1.416)]、尿素氮[SMD=-0.707,95%CI(-0.983,-0.431)]、肌酐[SMD=-1.448,95%CI(-1.763,-1.133)]差异均具有统计学意义,观察组尿酸、尿素氮、肌酐均较对照组低;由于结果的异质性较大,通过Meta回归分析探索异质性的来源,其中槲皮素的应用剂量[P=0.064,95%CI(0.999,1.024)]无统计学差异,造模方法和动物品系为分类变量,对其亚变量赋值后再进行Meta回归分析,结果显示造模方法(Adj R2=7.82%)中氧嗪酸钾(PO)[P=0.939,95%CI(0.003,171.394)]、次黄嘌呤(Hyp)[P=0.293,95%CI(0.051,11014.36)]、腺嘌呤(Ad)[P=0.602,95%CI(0.001,61.948)],动物品系(Adj R2=43.43%)中SD大鼠[P=0.509,95%CI(0.005,15.748)]、BALB/C小鼠[P=0.434,95%CI(0.052,723.130)]均无统计学差异,而ICR小鼠[P=0.023,95%CI(0.0001,0.416)]则具有统计学差异,它可以解释43.43%的异质性,且经蒙特卡洛检验后未发现一类错误。结论槲皮素在实验性高尿酸血症的研究中显示了充分的疗效,表现出更高的安全性。Objective To systematically evaluate the efficacy of quercetin in the treatment of experimental hyperuricemia. Methods A comprehensive search was conducted for randomized control trials（RCTs） on quercetin treating experimental hyperuricemia through online bibliographic databases including Pubmed,Medline,Embase,The Cochrane library,Wanfang,Vip,CNKI（China National Knowledge Infrastructure） and Google Scholar. Meta-analysis was carried out using Stata 12.0 after methodological quality assessment. Results A total of 7 RCTs concerning 187 animals were selected. In the methodological quality assessment,one scored 8, four scored 7 and two scored 5. The meta-analysis showed that the standardized mean differences（SMD） of serum uric acid, urea nitrogen and creatinine between the observation group and control group were SMD=-1.708,95%CI（-2.000,-1.416）,SMD=-0.707,95%CI（-0.983,-0.431） and SMD=-1.448,95%CI（-1.763,-1.133）respectively, indicating a high heterogeneity. The serum uric acid,urea nitrogen and creatinine in observation group were lower than those in control group. Therefore, the source of heterogeneity was traced by a meta-regression, which showed P=0.064,95%CI（0.999,1.024） for dose of quercetin,the method of hyperuricemia induction and strains of animals were categorical variables. Then these variables were assigned as dummy variables. Among different methods for induction of hyperuricemia（Adj R2=7.82%）, the results were P=0.939,95%CI（0.003,171.394） for potassium oxonate, P=0.293,95%CI（0.051,11014.36） for hypoxanthine and P =0.602,95%CI（0.001,61.948） for adenine. Among animal strains（Adj R2=43.43%）,the results were P=0.509,95%CI（0.005,15.748） for SD rats, P=0.434,95%CI（0.052,723.130） for BALB/c mice and P=0.023,95%CI（0.0001,0.416）for ICR mice, indicating that the heterogeneity was likely to be originated from ICR mice in animal strains, and it could explain 43.43% heterogeneity. The exclusion of type I error was confirmed by Monte carlo analysis. Conclusion

关 键 词：槲皮素 高尿酸血症 动物疾病模型 META分析 

分 类 号：R589.7[医药卫生—内分泌]