内质网氨肽酶2基因rs2549782多态性与妊娠期高血压发病的相关性  

Association between ERAP2 Gene rs2549782 Polymorphisms and Gestational Hypertension

作　　者：钮慧远[1] 金鑫[2] 张舒[2] 张丽萍[1] 朱晓红[1] 周杰[2] 郭浩伟 许良云[2] 潘琼[2] 

机构地区：[1]扬州大学医学院附属淮安市妇幼保健院产科,淮安223002 [2]扬州大学医学院附属淮安市妇幼保健院医学遗传与产前筛查科,淮安223002 [3]南京医科大学第一临床医学院

出　　处：《国际妇产科学杂志》2017年第6期636-641,共6页Journal of International Obstetrics and Gynecology

基　　金：江苏省妇幼健康科研项目(F201670);淮安市科技支撑计划项目(HAS2010018;HAS2009003)

摘　　要：目的:探讨内质网氨肽酶2(ERAP2)基因rs2549782多态性与淮安地区汉族女性妊娠期高血压发病的关系。方法:应用病例对照研究,收集2013年6月—2016年4月江苏省淮安市妇幼保健院确诊的汉族妊娠期高血压疾病患者100例为研究对象(病例组),同期住院分娩正常孕妇310例为对照(对照组),应用MassARRAY-IPLEX技术和基质辅助激光解吸离子飞行时间质谱(MALDI-TOF-MS)对ERAP2基因rs2549782位点进行基因分型。结果:2组中rs2549782位点等位基因分布差异无统计学意义(P=0.089),而基因型分布差异有统计学意义(P=0.045)。经校正混杂因素后,Logistic回归分析提示G等位基因(OR=1.64,95%CI:1.09~2.47)以及GT基因型(OR=2.23,95%CI:1.01~4.07)和GG基因型(OR=2.96,95%CI:1.20~7.31)为妊娠期高血压发生的危险因素。结论:ERAP2基因rs2549782位点单核苷酸多态性与淮安汉族妊娠期高血压疾病的发生具有相关性,G等位基因、GT和GG基因型均为妊娠期高血压的危险因素。Objective:To assess the association between single nucleotide polymorphism(SNP) of endoplasmic reticulum aminopeptidase 2(ERAP2) gene and hypertensive disease complicating pregnancy(HDCP) in ethnic Han Chinese in Huai ′an area. Methods:100 Han Chinese with HDCP and 310 normal controls were enrolled. Genotypes of rs2549782 within ERAP2 gene was determined with matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF-MS).Results:Distribution of G and T allele showed no significant difference between the two groups(P=0.089), but the distributions of genotypes presented statistically significant difference(P=0.045). After adjusted for confounding factors, results from logistic regression analysis indicated that G allele, GT and GG genotype were risk factors for HDCP in Huai ′an women population(OR=1.64, 95%CI: 1.09-2.47; OR=2.23, 95%CI: 1.01-4.07; OR=2.96, 95%CI: 1.20-7.31). Conclusions:This study suggested that rs2549782 polymorphism of the ERAP2 gene might be associated with GH in ethnic Han Chinese from Huai′ an area, the G allele, GT and GG genotype might increase the risk for HDCP.

关 键 词：氨肽酶类 高血压 妊娠性 多态性 单核苷酸 内质网氨肽酶2基因 

分 类 号：R714.246[医药卫生—妇产科学]