糖皮质激素联合抗生素对重症肺炎患者血清感染指标、急性蛋白及应激激素的影响  

Effects of glucocorticoid combined with antibiotics on serum infection indexes,acute phase proteins and stress hormones in patients with severe pneumonia

作　　者：于洋[1] 范捷[1] YU Yang;FAN Jie(Department of Western Medicine,Affilated Hospital of Jianghan Universit ,4300145, China)

机构地区：[1]江汉大学附属医院西药剂科,湖北武汉4300145

出　　处：《海南医学院学报》2017年第20期2765-2767,2771,共4页Journal of Hainan Medical University

基　　金：2015湖北省卫计委科研项目(WJ2015MA014)~~

摘　　要：目的:探讨糖皮质激素联合抗生素对重症肺炎患者血清感染指标、急性蛋白及应激激素的影响。方法:回顾性分析在本院治疗的重症肺炎患者80例,根据治疗方案不同分为接受常规抗生素治疗的常规治疗组46例、接受糖皮质激素联合抗生素治疗的联合治疗组34例,对比两组治疗前后感染指标、急性蛋白及应激激素的差异。结果:治疗前,两组血清中感染指标、急性蛋白及应激激素含量的差异无统计学意义(P>0.05)。治疗1周后,观察组血清中感染指标CRP、PCT的含量低于对照组;血清中急性蛋白α1-AT、α1-AG、CER的含量低于对照组;血清中应激激素Cor、AngⅠ、AngⅡ的含量低于对照组(P<0.05)。结论:重症肺炎患者接受糖皮质激素联合抗生素治疗,可有效抑制全身感染及应激状态,优化病情。Objective：To study the effects of glucocorticoid combined with antibiotics on serum infection indexes,acute phase proteins and stress hormones in patients with severe pneumonia.Methods：80 patients with severe pneumonia who were hospitalized between August 2014 and January 2017 were retrospectively analyzed and divided into the routine treatment group（n=46）who received conventional antibiotic therapy and the combined treatment group（n=34）who received glucocorticoid combined with antibiotic therapy,and the differences in infection indexes,acute proteins and stress hormones were compared between the two groups of patients before and after treatment.Results：The differences in serum levels of infection indexes,acute phase proteins and stress hormones were not statistically significant between the two groups before treatment（P〈0.05）.After 1 week of treatment,serum infection indexes CRP and PCT levels of observation group were lower than those of control group;serum acute phase proteins α1-AT,α1-AG and CER levels were lower than those of control group;serum stress hormones Cor,AngⅠ and AngⅡlevels were lower than those of control group（P〈0.05）.Conclusion：Glucocorticoid combined with antibiotics can effectively inhibit systemic infection and stress and optimize the illness in patients with severe pneumonia.

关 键 词：重症肺炎 糖皮质激素 抗生素 感染指标 急性蛋白 应激激素 

分 类 号：R563.1[医药卫生—呼吸系统]