益心康泰胶囊联合硫氮唑酮对不稳定型心绞痛患者内皮功能、血粘度及脂代谢的影响  

Effect of Yixinkangtai Capsule combined with diltiazem on endothelial function,blood viscosity and lipid metabolism in patients with unstable angina pectoris

作　　者：袁宇峰 薛大伦 

机构地区：[1]陕西省府谷县中医医院内科,陕西榆林719499 [2]陕西省安康市紫阳县中医医院内科,陕西安康725300

出　　处：《海南医学院学报》2017年第20期2768-2771,共4页Journal of Hainan Medical University

基　　金：陕西省科技攻关项目(2013JM4053)~~

摘　　要：目的:探讨益心康泰胶囊联合硫氮唑酮对不稳定型心绞痛患者内皮功能、血粘度及脂代谢的影响。方法:2014年2月-2017年2月间在本院接受治疗的不稳定型心绞痛患者150例,按照随机数表法分为对照组、研究组各75例。对照组患者接受临床常规治疗,研究组患者在常规治疗基础上加入益心康泰胶囊联合硫氮唑酮治疗,均持续3月。对比两组患者治疗前后内皮功能、血粘度、脂代谢的差异。结果:治疗前,两组患者血清中内皮功能指标、血粘度指标、脂代谢指标含量比较,差异无统计学意义(P>0.05)。治疗3月后,研究组血清中NO的含量高于对照组,ET-1的含量低于对照组(P<0.05);研究组血清中血粘度指标TXB2的含量低于对照组,PGI2的含量高于对照组(P<0.05);研究组血清中脂代谢指标TG、TC、LDL-C的含量低于对照组,HDL-C的含量高于对照组(P<0.05)。结论:不稳定型心绞痛患者接受益心康泰胶囊联合硫氮唑酮治疗,可有效优化内皮功能、降低血黏度、平衡脂代谢。Objective：To discuss the effect of Yixinkangtai Capsule combined with diltiazem on endothelial function,blood viscosity and lipid metabolism in patients with unstable angina pectoris.Methods：150 patients with unstable angina pectoris who were treated in the hospital between February 2014 and February 2017 were divided into the control group（n=75）and the research group（n=75）according to the random number table method.Control group received clinical conventional therapy,research group received Yixinkangtai Capsule combined with diltiazem therapy on the basis of conventional therapy,and both groups received 3 months of treatment.Differences in endothelial function,blood viscosity and lipid metabolism were compared between the two groups of patients before and after treatment.Results：Before treatment,the differences in serum levels of endothelial function indexes,blood viscosity indexes and lipid metabolism indexes were not statistically significant between the two groups（P〉0.05）.After 3 months of treatment,serum NO level of research group was higher than that of control group while ET-1 level was lower than that of control group（P〈0.05）;serum blood viscosity index TXB2 content of research group was lower than that of control group while PGI2 content was higher than that of control group）（P〈0.05）;serum lipid metabolism indexes TG,TC and LDL-C contents of research group were lower than those of control group while HDL-C content was higher than that of control group（P〈0.05）.Conclusion：Yixinkangtai Capsule combined with diltiazem therapy can effectively optimize the endothelial function,reduce the blood viscosity and balance the lipid metabolism in patients with unstable angina pectoris.

关 键 词：不稳定型心绞痛 益心康泰胶囊 内皮功能 血粘度 脂代谢 

分 类 号：R541[医药卫生—心血管疾病]