输尿管软镜碎石术与经皮肾镜碎石术对肾结石患者炎性因子、氧化应激及应激激素水平的影响  

Effect of flexible ureteroscope lithotripsy and percutaneous nephrolithotomy on the levels of serum inflammatory factors,oxidative stress and stress hormone in patients with renal calculi

作　　者：梁苏东[1] 吕高飞 阮亚石[1] 郑明华[1] 牛天力[1] 

机构地区：[1]江苏省泰州市人民医院泌尿外科,江苏泰州225300 [2]湖南省永州市中心医院泌尿外科,湖南永州425000

出　　处：《海南医学院学报》2017年第20期2783-2786,共4页Journal of Hainan Medical University

基　　金：江苏省卫生厅科技项目(Y201514)~~

摘　　要：目的:探讨输尿管软镜碎石术与经皮肾镜碎石术对肾结石患者炎性因子、氧化应激及应激激素水平的影响。方法:选取97例肾结石患者作为研究对象,随机分为对照组(n=49)和观察组(n=48),对照组行经皮肾镜碎石术(PCNL)治疗;观察组行输尿管软镜碎石术(FURL)治疗,比较术前及术后1d两组炎性因子[白细胞介素-10(IL-10)、C反应蛋白(CRP)、白细胞(WBC)]、氧化应激[丙二醛(MDA)、超氧化物歧化酶(SOD)]及应激激素[皮质醇(COR)、促肾上腺皮质激素(ACTH)、去甲肾上腺素(NE)]水平。结果:术前,两组间IL-10、CRP、WBC、COR、ACTH、NE、MDA及SOD水平比较,差异无统计学意义(P>0.05);与组内术前水平相比,两组术后1dIL-10、CRP、WBC、COR、ACTH、NE、MDA水平均显著升高,且观察组水平显著低于对照组,差异有统计学意义(P<0.05);术后1d两组SOD水平均显著低于组内术前水平,且对照组显著低于观察组,差异有统计学意义(P<0.05)。结论:与经皮肾镜碎石术相比,输尿管软镜碎石术对肾结石患者产生的应激反应小,更有利于术后恢复,具有重要临床价值。Objective：To investigate the effects of flexible ureteroscope lithotripsy and percutaneous nephrolithotomy on the levels of serum inflammatory factors,oxidative stress and stress hormone in patients with renal calculi.Methods：97 cases of renal calculi patients were chosen as the research object,based on the random data table,they were divided into the control group（n=49）and the observation group（n=48）,patients in the control group underwent percutaneous nephrolithotomy（PCNL）treatment,while the observation group patients were treated with flexible ureteroscope lithotripsy（FURL）,before and after 1 d,the levels of inflammatory factors[interleukin-10（IL-10）,C reactive protein（CRP）,white blood cell（WBC）],stress hormone[cortisol（COR）,adrenocorticotropic hormone（ACTH）,norepinephrine（NE）]and oxidative stress[malondialdehyde（MDA）,superoxide dismutase（SOD）]of the two groups were compared.Results：There were no significant differences in IL-10,CRP,WBC,COR,ACTH,NE,MDA and SOD levels between the two groups preoperative（P〉0.05）;Compared with the preoperative level in the group,the 1 dpostoperatively levels of IL-10,CRP,WBC,COR,ACTH,NE and MDA in the two groups were significantly increased,and the level of the observation group was significantly lower than that in the control group（P〈0.05）;The levels of SOD in the two groups 1 dpostoperatively were significantly lower than those in the same group preoperative,and the control group（85.65±9.95）U/ml was significantly lower than that of the control group（94.71±7.63）U/ml（P〈0.05）.Conclusion：Compared with percutaneous nephrolithotomy,flexible ureteroscopic lithotripsy for renal calculi is less stressful and more favorable for postoperative recovery,has an important clinical value.

关 键 词：肾结石 输尿管软镜碎石术 经皮肾镜碎石术 炎性因子 氧化应激 应激激素 

分 类 号：R692.4[医药卫生—泌尿科学]