基于Mn掺杂ZnS量子点室温磷光检测头孢克肟  

Detection of CEF based on the room temperature phosphorescence of MPA-capped Mn-doped ZnS quantum dots

作　　者：于建敏[1] 栗东霞[1] 安昭琦 闫桂琴[1] 

机构地区：[1]山西师范大学生命科学学院,山西临汾041000

出　　处：《应用化工》2017年第12期2492-2496,共5页Applied Chemical Industry

基　　金：国家教育部博士点联合基金项目(20111404110002);山西省重点化学优势学科建设项目(912019)

摘　　要：在室温下,利用巯基丙酸(MPA)包裹Mn掺杂ZnS量子点的磷光信号,建立一种检测头孢克肟(CEF)的新方法。在最佳条件下(0.4 mg/L量子点溶液和pH=7.4磷酸缓冲液),CEF的加入使MPA包裹的Mn掺杂ZnS量子点的室温磷光发生猝灭,磷光强度(ΔRTP)与CEF呈现良好的线性关系,其线性范围1.2~24μmol/L,最低检出限0.49μmol/L,相关系数0.993,实际样品的检测回收率为93.7%~101.3%。该方法简便快速、成本低、选择性好等,能够用于人体液中CEF含量的分析。Using these( MPA)-capped Mn-doped ZnS quantum dots( QDs) emit strong phosphorescence at room temperature,a novel method for the determination of cefixime( CEF) has been developed. It was found that under optimum conditions,i. e. 0. 4 mg/L quantum dots buffer and PBS buffer( pH = 7. 4),the addition of cefixime could obviously quench the room temperature phosphorescence of MPA-capped Mndoped ZnS quantum QDs,the quenched phosphorescence intensity( ΔRTP) was linearly proportional to concentration of cefixime( CEF). The linear ranges of cefixime( CEF) were 1. 2 ~ 24 μmol/L,the minimum detectable limit were 0. 49 μmol/L,with correlation coefficients of 0. 993,respectively. The results samples are with recovery rate of 93. 7% ~ 101. 3%. The method is simple,rapid and can be used well for analysis and detection of CEF in body fluid.

关 键 词：量子点 头孢克肟 室温磷光 检测 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.3[化学工程—制药化工]