Ultra-low charge transfer resistance carbons by onepot hydrothermal method for glucose sensing  

一步水热法合成超低电荷转移阻抗的碳材料及其葡萄糖检测性能研究（英文）

作　　者：胡博韬 刘仁材 陈靖容 赵湛 张淑真 康沛伦 

机构地区：[1]College of Materials Science and Opti-Electronic Technology, University of Chinese Academy of Sciences, Beijing 101408 [2]School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408 [3]State Key Lab of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100089 [4]Department of Electric Engineering, I-Shou University, Kaohsiung 82445 [5]Cardiovascular Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 82445

出　　处：《Science China Materials》2017年第12期1234-1244,共11页中国科学（材料科学（英文版）

基　　金：supported by the National Basic Research Program of China (973 Program,2014CB931900);UCAS Young Teacher Research Fund (Y55103NY00,Y55103EY00,and Y25102TN00);Beijing Natural Science Foundation (Z160002);The Chinese Academy of Sciences Key Project Foundation (KFZD-SW-202)

摘　　要：Hydrothermal carbon （HTC） is typically well- dispersed, but it remains a great challenge for HTC to become conductive. Co-doping with heteroatoms has been confirmed to be an effective strategy to significantly promote the electrical conductivity of carbon. Moreover, there is no simple and green method to construct sensitive HTC based electro- chemical biosensors until now. In this paper, N and S dual-doped carbon （NS-C） with ultra-low charge transfer resistance is easily synthesized from L-cysteine and glucose in a hydrothermal reaction system. The morphology, structural prop- erties and electrochemical properties of the as-prepared NS-C are analyzed. In comparison with the undoped hydrothermal （UC） modified glassy carbon electrode （GCE）, the charge transfer resistance of UC （476 Ω） is ten times the value of NS- C （46 Ω）. The developed biosensor shows a better performance to detect glucose in a wide concentration range （50-2500 μmol L^-1） with the detection limit of 1.77 μmol L^-1 （S/N-3） and a high sensitivity （0.0554 μA cm^-2μmol^-1 L）. The apparent Michaelis-Menten constant value of GCE/NS-C/GOx/nafion modified electrode is 0.769 mmol L^-1, indicating a high affinity of glucose oxidase to glucose. These results demonstrate that the hydrothermal method is an effective way for prepar- ing high electrical conductivity carbon with excellent performances in biosensor application.水热碳材料具有较好的水溶性,但是通常表现为绝缘性,因此提高水热碳材料的导电性仍然是一个重大挑战.化学掺杂已经被证实能够显著提高碳材料的导电性,但目前尚没有一种简单且绿色的方法制备高灵敏度水热碳基的电化学传感器.本文在水热反应体系中用L-半胱氨酸和葡萄糖合成了超低电子转移阻抗的氮硫掺杂碳材料,随后分析了材料的形貌、结构和电化学性质.氮硫掺杂碳修饰电极电子转移阻抗(46Ω)大约是非掺杂碳修饰电极(476Ω)的1/10.氮硫掺杂碳材料制备的葡萄糖传感器具有较宽线性范围(50–2500μmol L^(-1)),低的检测限(1.77μmol L^(-1),S/N=3)和高的灵敏度(0.0554μA cm^(-2)μmol L^(-1)).GCE/NS-C/GOx/nafion电极的米氏常数为0.769 mmol L^(-1),表明NS-C负载的葡萄糖氧化酶(GOx)对葡萄糖具有较高亲和力.本研究提出以水热法合成具有高电导性的碳材料,并应用于高性能的葡萄糖传感器.

关 键 词：hydrothermal method glucose biosensor charge transfer resistance heteroatom doped carbon electrochemical behavior 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] TQ127.11[自动化与计算机技术—控制科学与工程]