真空间歇精馏法分离紫罗兰酮异构体  

Separation of ionone isomers by vacuum batch distillation

作　　者：束铭杰 潘鹤林[1] 吴艇港 戴万里 SHU Ming-jie;PAN He-lin;WU Ting-gang;DAI Wan-li(School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, Chin)

机构地区：[1]华东理工大学化工学院,上海200237

出　　处：《现代化工》2017年第12期160-163,共4页Modern Chemical Industry

摘　　要：采用真空间歇精馏法实现了α-紫罗兰酮和β-紫罗兰酮异构体混合物的分离,考察了原料液组成、回流比、塔顶采出率、塔釜加热温度、塔节保温温度对异构体分离的影响,同时探讨了精馏操作时间对产品质量的影响。结果表明,在适宜的精馏操作条件下,塔釜产品β-紫罗兰酮的质量分数高于96%,同时收率能保持在90%以上,满足医药中间体应用要求。α-Ionone and β-ionone are separated by vacuum batch distillation. The effects of raw material composition,reflux ratio,recovery ratio at the top of the tower,tower kettle heating temperature and tower section heat preservation temperature on isomers separation are investigated.Moreover,the influences of distillation operation time on product quality are also studied. The results show that under the moderate distillation operating conditions,the mass fraction of β-ionone in the tower kettle is higher than 96%,and the yield remains above 90%,meeting the requirements of pharmaceutical intermediates.

关 键 词：紫罗兰酮 异构体 真空 间歇精馏 分离 

分 类 号：TQ655[化学工程—精细化工]