老年女性2型糖尿病患者合并骨质疏松的临床因素分析  

The analysis of clinical factors of the occurrence of type 2 diabetes in elderly women patients with osteoprosis

作　　者：应蓉[1] 龚仪雯 顾涛[1] 周吉[1] 庄丽英[1] 周营[1] 戈少红 蔡杏娟 YING Rong;GONG Yi-wen;GU Tao;ZHOU Ji;ZHUANG Li-ying;ZHOU Ying;GE Shao-hong;CAI Xing-juan(Department of Endocrinology, Shanghai Huangpu District Central Hospital, Shanghai 200002, Chin)

机构地区：[1]上海市黄浦区中心医院内分泌科,上海200002

出　　处：《中国医刊》2017年第12期51-54,共4页Chinese Journal of Medicine

基　　金：上海市黄浦区科学技术委员会科研项目(HKW201510)

摘　　要：目的探讨老年女性2型糖尿病患者合并骨质疏松的临床因素。方法选取2015年1月至2016年8月于本院住院的老年女性2型糖尿病患者136例,以骨密度T值为标准分为3组:骨量正常组(T≥-1.0)、骨量减少组(-2.5<T<-1.0)和骨质疏松组(T≤-2.5)。比较3组患者的生化指标及年龄、体重指数(body mass index,BMI)、病程等,采用Logistic回归分析骨质疏松的危险因素。结果骨质疏松组的年龄、糖尿病病程、糖化血红蛋白(hemoglobin A1c,Hb A1c)、绝经年限高于骨量正常组和骨量减少组,BMI低于骨量正常组和骨量减少组,差异有显著性(P<0.05)。3组的空腹血糖、餐后2小时血糖、血钙、血磷、胰岛素、C-肽、肌酐、25-羟-维生素D3、甲状旁腺素、总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白等比较差异无显著性(P>0.05)。Logistic回归分析显示,老年女性2型糖尿病合并骨质疏松与绝经年限、Hb A1c呈正相关,与BMI呈负相关。结论老年女性2型糖尿病合并骨质疏松与多因素有关,包括绝经年限长、低BMI、高Hb A1c。Objective To investigate the clinical factors of type 2 diabetes in elderly women patients with osteoprosis. Method Clinical data of type 2 diabetes in elderly women patients were collected. All patients were divided into three groups：normal bone mass group（T≥-1.0 SD）, decreased bone mass group（-2.5 SDT-1.0 SD）, osteoprosis group（T≤-2.5 SD）. The laboratory results, age, BMI, course of disease among three groups were compared. Logistic regressions analysis was used to analyze its risk factors. Result Compared with normal bone mass group and decreased bone mass group, there were more older patients, longer duration of T2 DM, higher levels of Hb A1 c, longer menopause duration and lower BMI in menopause group. The difference was statistically significant（P〈0.05）. Among three groups, the levels of FBG, 2 h PG, serum phosphorus,serum calcium, insulin, C-peptide, serum creatinine, serum 25-OH-D3, PTH, TC, TG, LDL and HDL were not statistically different（P〈0.05）. Logistic regressions analysis showed that elderly women patients with OP had a positive correlation with menopause duration and Hb A1 c, but a negative correlation with BMI. Conclusion Elderly women patients with OP are related to a number of risk factors, including longer menopause duration, lower BMI, higher levels of HbA1c.

关 键 词：糖尿病 女性 骨质疏松 骨密度 

分 类 号：R587.1[医药卫生—内分泌]