孕妇血清淀粉样蛋白A水平检测与早期原发性不明原因复发性流产的临床相关性研究  

Clinical Research on Detecting the Serum Amyloid A Level of Pregnant Woman in Early Primary Unexplained Recurrent Spontaneous Abortion

作　　者：曹英[1] 刘春华[1] 杨亚莉[1] 

机构地区：[1]宝鸡市妇幼保健院产科,陕西宝鸡721000

出　　处：《现代检验医学杂志》2017年第6期43-45,49,共4页Journal of Modern Laboratory Medicine

基　　金：宝鸡市2013年科学技术研究发展计划项目(13SF4_2)

摘　　要：目的检测原发性不明原因早期复发性流产(recurrent early pregnancy loss,REPL)孕妇血清淀粉样蛋白A(serum amyloid A,SAA)水平,并探讨其对不明原因REPL的预测价值。方法将2014年1~12月间宝鸡市妇幼保健院妇产科收治的96例原发性不明原因REPL孕妇作为REPL组,并以96例无REPL史的正常孕妇作为对照组。采用酶联免疫法检测两组患者血清SAA水平,多因素Logistic回归分析REPL发病的危险因素,并采用ROC曲线评估SAA对REPL的诊断价值。结果 REPL组孕妇血清SAA中位浓度(50.0μg/ml)显著高于正常孕妇(11.6μg/ml)(Z=2.153,P=0.000<0.01)。SAA对REPL的诊断价值较高(AUC=0.91),最佳筛查阳性界值为18μg/ml。矫正孕妇年龄和孕周因素,SAA水平是原发性不明原因REPL发生的危险因素(OR值:1.12,P=0.000)。结论原发性不明原因REPL孕妇血清SAA水平升高可作为REPL发病的新的生物标志。Objective To research the serum amyloid A（SAA）levels of primary unexplained recurrent early pregnancy loss （REPL）,and discuss the viability of regarding the SAA as a independent indicator of REPL.Methods A prospective study was conducted among 96 women with missed spontaneous abortion at Baoji Maternal and Child Care Hospital from January to December 2014.A control group was formed of pregnant women with no history of REPL.Serum samples of both groups were collected to measure SAA levels by enzyme linked immunosorbent assay.The association between SAA and primary unexplained REPL were analyzed according to the multiple factors Logistic models,and the diagnostic value of SAA to RE-PL were detected through receiver operating characteristic.Results Median SAA level was significantly higher among women with REPL（50 μg/ml,interquartile range 26.0~69.0 μg/ml）,than that in the control group（11.6 μg/ml,inter-quartile range 6.2~15.5 μg/ml,P=0.000〈0.01）.The diagnose value of SAA to REPL was perfect good（AUC=0.91）, and the most accurate value was 18 μg/ml.The SAA level was an independent indicator of primary unexplained REPL,after adjusting for maternal age and gestational age（OR：1.12,P=0.000）.Conclusion Elevated SAA levels found among women with primary unexplained REPL could represent a novel biomarker for this complication of pregnancy.

关 键 词：原发性不明原因早期复发性流产 血清淀粉样蛋白A 合胞体化 滋养细胞侵入 

分 类 号：R714.21[医药卫生—妇产科学] R392.11[医药卫生—临床医学]