机构地区:[1]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所心脏外科中心,100029 [2]河北医科大学第三医院心脏外科
出 处:《中华儿科杂志》2017年第12期932-936,共5页Chinese Journal of Pediatrics
摘 要:目的评价胸部电抗电子心力监测(EV)在先天性心脏病患儿体外循环术后液体管理的临床应用价值。方法前瞻性观察2016年7—11月在河北医科大学第三医院和北京安贞医院收治的60例简单先天性心脏病患儿(室间隔缺损48例,房间隔缺损12例),按数字随机表方式分为两组:EV监测治疗组30例和传统中心静脉压(CVP)监测治疗组30例。EV组根据监测的每搏输出量变异度(SVV),调整液体入量及血管活性药物用量。CVP组则根据监测的CVP、血压、心率、尿量、血气分析等经验性给予液体管理治疗。观察并记录两组患儿术后后2、4、6 h的心率(HR)、平均动脉压(MAP)、血浆乳酸(Lac)水平、氧合指数(PaO2/FiO2),机械通气时间,重症监护病房(ICU)滞留时间等。应用EV测得SVV值与PhilipsHD彩色多普勒超声仪检查下腔静脉扩张指数(dIVC)进行Pearson相关性分析。结果术后2、4、6 h时MAP水平EV组高于CVP组,差异有统计学意义[(62±10)比(50±6)mmHg(1 mmHg=0.133 kPa),(68±11)比(59±4)mmHg,(71±6)比(63±8)mmHg,t=5.580 9、4.530 1、4.308 1,P=0.000 1、0.000 2、0.000 1],2、4、6 h PaO2/FiO2 EV组高于CVP组,差异有统计学意义(362±23比310±43、380±33比330±38、386±57比350±63,t=5.818 8、5.419 2、2.317 2,P=0.002、0.001、0.024);而2、4、6 h心率水平EV组低于CVP组,差异有统计学意义[(166±10)比(179±14)次/min、(156±11)比(168±16)次/min、(138±10)比(149±13)次/min,t=3.930 7、3.511 1、3.671 5,P=0.000 2、0.000 9、0.000 5]; 2、4、6 h Lac(+)率水平EV组低于CVP组,差异有统计学意义(7%比33%、3%比20%、0比13%、χ2=5.104 2、4.043 1、4.285 7, P=0.045 3、0.044 4、0.038 4);2、4、6 h dIVC (+)率水平EV组低于CVP组,差异有统计学意义(13%比33%、7%比20%、0比13%,χ2=3.854 0、3.942 1、4.285 7, P=0.047 0、0.023 9、0.038 4)�ObjectiveTo investigate the clinical applicability of electrical velocimetry (EV) in monitoring pediatric blood volume after cardiopulmonary bypass.MethodBetween July 2016 and November 2016, 60 children with congenital heart disease were divided into EV group and traditional central venous pressure (CVP) group randomly. For EV group, the volume of fluid and vascular active medicine was adjusted according to the monitoring stroke volume variation (SVV) hemodynamic parameters. Whereas for CVP group empirical volume of fluid infusion was managed by the monitoring traditional hemodynamic parameters such as CVP, blood pressure, heart rate, urine volume and blood gas analysis.Heart rate (HR), mean artery pressure (MAP), blood lactic acid (LA), oxygenation index (PaO2/FiO2) at 2, 4 and 6 h after operation were observed and compared between two groups. Mechanical ventilation time and ICU monitoring time were also compared between two groups. Pearson correlation analysis was performed to investigate the significance of SVV and inferior vena cava expansion index (dIVC) for evaluating of reactivity capacity after surgery.ResultMAP level was significantly higher in EV group at 2, 4, and 6 h after operation [ (62±10) vs. (50±6) mmHg(1 mmHg=0.133 kPa), (68±11) vs.(59±4) mmHg, (71±6) vs. (63±8) mmHg respectively; t=5.580 9, 4.530 1, 4.308 1; P=0.001, 0.002, 0.001]. PaO2/FiO2 ratio was higher in EV group than that of CVP group[ (362±23) vs. (310±43), (380±33) vs. (330±38), (386±57) vs. (350±63.1) respectively, t=5.818 8, 5.419 2, 2.317 2; P=0.002, 0.001, 0.024]. However HR and blood lactic acid level was lower in EV group than the CVP group [(166±10) vs. (179±14)/min, (156±11) vs. (168±16)/min, (138±10) vs. (149±13)/min respectively; t=3.930 7, 3.511 1, 3.671 5; P=0.002, 0.009, 0.005]; [7% vs. 33%, 3% vs. 20%, 0 vs. 13%, χ2=5.104 2、4.043 1、4.285 7, P=0.045 3, 0.044 4, 0.038 4] respectively; Mechanica
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...