组蛋白赖氨酸巴豆酰化修饰的研究进展  

Research progress on histone lysine crotonylation

作　　者：杨强震 李培飞 李新红[1] YANG Qiang-Zhen;LI Pei-Fei;LI Xin-Hong(Shanghai Key Lab of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, Chin)

机构地区：[1]上海交通大学农业与生物学院上海市兽医生物技术重点实验室,上海200240

出　　处：《生命科学》2017年第11期1126-1132,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31772594);上海市科技兴农重点基础研究项目(沪农科基字(2014)第2-5号)

摘　　要：组蛋白赖氨酸巴豆酰化修饰是2011年新发现的一种酰化修饰,对基因表达、细胞发育以及疾病治疗等生物过程具有重要的生物学意义。近两年内,巴豆酰化修饰生化相关研究取得突破性进展,尤其是在蛋白巴豆酰化修饰的生理功能以及与发育、遗传、疾病相关性等领域逐渐受到关注。现对蛋白巴豆酰化做一简要回顾,总结组蛋白巴豆酰化修饰鉴定、相关酶系统、识别结构域及生物学功能等,这些信息为将来进一步探索蛋白巴豆酰化的功能提供理论基础。Histone lysine crotonylation （Kcr） was identified as an emerging histone acylation in 20ll. Recent studies suggest that Kcr plays a significant role in gene expression, cell development and disease therapy. Most researches concentrating on biochemistry of Kcr have obtained considerable development, and the physiological functions of Kcr begun to get attention in recent years. In this review, we make a brief discussion on the identification of Kcr, writers and erasers of Kcr, crotonylation reader proteins and Kcr biological functions, which include regulation of gene expression, sustaining transcription during meiotic sex chromosome inactivation and functions of non-histone Kcr. This knowledge is theoretical basis for the future exploration of lysine crotonylation.

关 键 词：蛋白质翻译后修饰 组蛋白赖氨酸巴豆酰化 赖氨酸巴豆酰化酶 生物学功能 

分 类 号：Q519[生物学—生物化学]