不同剂量丹参注射液联合匹多莫德治疗儿童过敏性紫癜的效果分析  

Efficacy analysis of different doses danshen injection combined with pidotimod in the treatment of child's henoch schonlein purpura

作　　者：刘杰[1] 岑敏[2] 王冠[1] 

机构地区：[1]鄂东医疗集团黄石市中心医院儿科,湖北黄石435000 [2]鄂东医疗集团黄石市中心医院普爱院区儿科,湖北黄石435000

出　　处：《河北医科大学学报》2018年第1期73-76,81,共5页Journal of Hebei Medical University

摘　　要：目的比较不同剂量丹参注射液联合匹多莫得对儿童过敏性紫癜的临床效果。方法将黄石市中心医院儿科收治的152例过敏性紫癜患儿随机分为3组,分别为匹多莫德组(49例)、常规剂量联合组(51例)和大剂量联合组(52例)。所有患儿均给予常规治疗,匹多莫德组加用匹多莫德400mg/d,常规剂量联合组给予丹参注射液10mL/d+匹多莫德400mg/d,大剂量联合组给予丹参注射液20mL/d+匹多莫德400mg/d,疗程持续14d,观察记录3组临床症状消失时间、6个月后复发率、治疗前后外周血中免疫功能和氧化应激指标变化,并比较临床疗效。结果治疗14d后,常规剂量联合组和大剂量联合组临床症状(紫癜、腹痛、关节痛、皮疹及肾脏损害)消失时间均短于匹多莫德组,大剂量联合组临床症状消失时间短于常规剂量组(P<0.05)。随访6个月后,大剂量联合组复发率低于匹多莫德组和常规剂量联合组(P<0.05)。与治疗前相比,3组血浆谷胱甘肽过氧化物酶、超氧化物歧化酶、CD3+、CD4+、CD8+及CD4+/CD8+含量均得到改善,但大剂量联合组较另外2组改善更为明显,常规剂量联合组较匹多莫德组改善明显(P<0.05)。匹多莫德组治愈率和总有效率均低于常规剂量联合组和大剂量联合组,且常规剂量联合组治愈率和总有效率均低于大剂量联合组(P<0.05)。结论应用大剂量丹参注射液联合匹多莫德治疗儿童过敏性紫癜能取得较好的临床疗效,有效降低复发率,安全可靠,值得在临床上应用。Objective To compare the clinical efficacy of different doses danshen injection combined with pidotimod in the treatment of henoch schonlein purpura(HSP).Methods A total of 152 cases of children with HSP admitted into pediatric department of Huangshi central hospital were randomly divided into three groups:pidotimod group(n = 49),conventional-dose combination group(n=51)and large dose combination group(n=52).Three groups all were received conventional medical treatment,Pidotimod group accepted pidotimod 400 mg/d,conventional-dose combination group accepted Danshen injection 10 mL/d combined with pidotimod 400 mg/d,while the large dose group accepted Danshen injection 20 mL/d combined with pidotimod 400 mg/d.The treatment course lasted for 2 weeks.The clinical symptoms disappeared time,the recurrence rate after 6 months,peripheral blood immune function,oxidative stress parameters contents before and after the treatment and the clinical efficacy of 3 groups were recorded.Results The clinical symptoms including purpura,abdominal pain,joint pain,skin rashes and kidney damage disappeared time of conventional-dose combination group and large dose combination group were lower than that of pidotimod group,that of large dose combination group was lower than that of conventional-dose combination group(P<0.05).The recurrence rate of large dose combination group was significantly lower than that of other group by six months follow-up time(P< 0.05). After treatment,the glutathione peroxidase,superoxide dismutase,CD3+,CD4+,CD8+and CD4+/CD8+of three groups were all improved,but large combination dose group was better than the other two groups,conventional-dose combination was better than the pidotimod groups(P<0.05).The cure rate and total effective rate of pidotimod group was lower than that in conventional-dose combination group and large combination dose group,the conventional-dose combination group was lower than large combination dose group,all the differences were statistically significant(P<0.05).ConclusionLarge dose dan

关 键 词：紫癜 过敏性 丹参注射液 匹多莫德 儿童 

分 类 号：R554.6[医药卫生—血液循环系统疾病]