外周血PLT计数、Fib、FDP、DD在评估鼻咽癌预后中的价值  

Peripheral blood PLT,Fib,FDP and DD in the prognosis of nasopharyngeal carcinoma

作　　者：夏欢[1] 巫翠云[1] 何金龙[2] 

机构地区：[1]海口市人民医院检验科,海口海南571202 [2]海南医学院第一附属医院检验科,海口海南570102

出　　处：《检验医学》2017年第12期1085-1088,共4页Laboratory Medicine

基　　金：海南省卫生厅普通科研课题(琼卫2012-PT62)

摘　　要：目的探讨血小板(PLT)、纤维蛋白原(Fib)、纤维蛋白原降解产物(FDP)、D-二聚体(DD)含量变化与鼻咽癌(NPC)预后的关系,为NPC患者巩固疗效、预后判断提供新的思路。方法选取NPC患者113例(NPC组)、鼻咽部良性肿瘤患者30例(鼻咽部良性肿瘤组)、鼻咽炎症患者30例(鼻咽炎症组)及体检健康者30名(健康对照组),采用SYSMEX CA7000全自动血凝分析仪检测4个组Fib、FDP和DD水平;采用BECKMAN-COULTER LH750全自动血液分析仪计数4个组的PLT数量,并采用统计学软件进行分析。结果 NPC患者在初次入院时Fib、FDP、DD水平均显著高于鼻咽部良性肿瘤组、鼻咽炎症组和健康对照组(P<0.05),PLT计数则显著高于鼻咽部良性肿瘤组和健康对照组(P<0.05);NPC 3年未复发组出院前PLT计数、FDP水平较入院时显著下降(P<0.05);NPC 3年复发组出院前PLT计数、Fib、FDP水平较入院时显著下降(P<0.05),再入院时PLT、FDP、DD水平与出院前相比显著升高(P<0.05),FDP、DD与初次入院时相比也显著升高(P<0.05)。结论 PLT计数、Fib、FDP、DD水平检测对NPC诊断及预后判断有一定的价值。Objective To investigate the relationships of platelet（PLT）,fibrinogen（Fib）,fibrinogen degradation product（FDP）,D-dimer（DD） with the prognosis of nasopharyngeal carcinoma（NPC）,and to provide a reference on the prognosis of NPC. Methods Blood samples were collected from 113 patients with NPC, 30 patients with nasopharynx benign tumor,30 patients with nasopharyngitis and 30 healthy subjects. The levels of Fib,FDP and DD were determined by SYSMEX CA7000 automatic coagulation analyzer,and the count of PLT was determined by BECKMAN-COULTER LH750.Results The levels of Fib,FDP and DD in NPC group were higher than those in nasopharynx benign tumor,nasopharyngitis and healthy control groups（P〈0.05）,and the count of PLT was higher than those in nasopharynx benign tumor and healthy control groups（P〈0.05）. In NPC group without recurrence within 3 years,the count of PLT and the level of FDP were decreased when they left hospital compared with those being hospitalized（P〈0.05）. In NPC group with recurrence within 3 years,the count of PLT and the levels of Fib and FDP were decreased when they left hospital compared with those being hospitalized（P〈0.05）. When they were hospitalized again,the count of PLT and the levels of FDP and DD were increased significantly. Compared with those being hospitalized firstly,the levels of FDP and DD were increased as well. Conclusions The determinations of PLT count,Fib,FDP and DD play roles in the prognosis identification of NPC.

关 键 词：鼻咽肿瘤 血小板 纤维蛋白原 纤维蛋白原降解产物 D-二聚体 预后 

分 类 号：R446.1[医药卫生—诊断学]