血清胃蛋白酶原、胃泌素17联合检测在健康体检中的应用价值  

Combined determination of serum pepsinogen and gastrin 17 in healthy examination

作　　者：卢旬[1] 郑维玲[1] 宋妙丽[1] 杨辰[1] 

机构地区：[1]南京医科大学附属苏州医院核医学科,江苏苏州215002

出　　处：《检验医学》2017年第12期1095-1098,共4页Laboratory Medicine

摘　　要：目的探讨血清胃蛋白酶原(PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ比值(PGR)、胃泌素17(G-17)在健康体检中的价值。方法采用酶联免疫吸附试验(ELISA)检测1 872名表观健康者血清PGⅠ、PGⅡ、G-17水平,并计算PGR。分析性别、年龄与血清PGⅠ、PGⅡ、PGR、G-17的关系,以PG和G-17同时阳性作为筛查方案,比较其与胃镜检查结果的符合率。结果表观健康人群男、女性之间血清PGⅠ水平、PGR差异均有统计学意义(P<0.001),而PGⅡ、G-17水平差异无统计学意义(P>0.05)。随着年龄的增长,PGⅠ和PGⅡ水平逐渐上升,而PGR则呈下降趋势。血清G-17在21~50岁时为平台期,50岁之后G-17水平逐渐上升。男、女性之间血清PG、G-17阳性率以及PG与G-17同时阳性的比例差异均无统计学意义(P>0.05)。G-17阳性率明显高于PG阳性率(P<0.001)。PG和G-17同时阳性的筛查方案与胃镜检查结果的阳性符合率为12.5%。结论血清PG、G-17联合检测对胃相关疾病的筛查具有重要意义,适合在体检人群中推广。Objective To investigate the roles of serum pepsinogen（PG）Ⅰ,PGⅡ,pepsinogenⅠ/pepsinogenⅡ ratio（PGR） and gastrin 17（G-17） in healthy examination. Methods The levels of serum PGⅠ, PGⅡ and G-17 were determined by enzyme-linked immunosorbent assay（ELISA） in 1872 healthy subjects. PGR was calculated. The relations of serum PGⅠ,PGⅡ,PGR and G-17 with sex and age were evaluated. The results of the combined determination of serum PG and G-17 were compared those of gastroscopy. Results The levels of serum PGⅠand PGR had statistical significance between males and females（P〈0.001）,while the levels of PGⅡand G-17 had no statistical significance（P＆gt;0.05）. The levels of serum PGⅠ and PGⅡ were increased with the increasing of ages,while PGR was decreased. Serum G-17 reached a plateau in 21-50 years old,while it was gradually increased after 50 years old. There was no statistical significance in the positive rates of serum PG and G-17 and the double positive rate of serum PG and G-17 between males and females（P＆gt;0.05）,and the positive rate of serum G-17 was higher than that of serum PG（P〈0.001）.Compared with the results of gastroscopy,the positive coincidence rate of the combined determination of serum PG and G-17 was 12.5%.Conclusions The combined determination of serum PG and G-17 is important in the screening of gastric-related diseases,which can be applied in healthy examination.

关 键 词：胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ 胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ比值 胃泌素17 健康体检 

分 类 号：R446.1[医药卫生—诊断学]