双相障碍共病肥胖的性别差异  

Gender difference of obesity in bipolar disorder

作　　者：许晶晶[1] 方贻儒[1] 

机构地区：[1]上海交通大学医学院附属精神卫生中心心境障碍科,上海200030

出　　处：《上海交通大学学报（医学版）》2017年第12期1695-1698,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873);"十二五"国家科技支撑项目(2012BAI01B04)~~

摘　　要：双相障碍是情绪起伏不定、症状复杂多变的精神疾病。双相障碍患者代谢综合征患病率显著高于单相抑郁障碍和健康人群,且风险与抑郁严重程度及腹型肥胖有关。双相障碍共病肥胖存在性别差异,可能与童年不幸、偏头痛、激素水平改变、药物作用、饮食、生活方式等方面有关。文章从双相障碍临床特点及导致性别差异存在的可能机制进行综述。Bipolar disorder （BD） is a kind of psychiatric disorder with wildly alternating emotion and complicated symptoms. Subjects with BD had a significantly higher prevalence of metabolic syndrome when compared to subjects with major depressive disorder and non-psychiatric controls, with risk related to a higher depression score and abdominal obesity. Gender difference in the patients with BD and obesity may be related to childhood adversity, migraine, hormonal alterations, psychotropic medications, diet and lifestyle factors. This article reviewed clinical features and the potential mechanism of gender difference in bipolar disorder with comorbidity of obesity.

关 键 词：双相障碍 肥胖 性别 代谢综合征 

分 类 号：R589.2[医药卫生—内分泌] R749.4[医药卫生—内科学]