六分钟步行运动训练对慢性心力衰竭患者血浆肾素和血管紧张素Ⅰ的影响  

Effect of Six-Minutes Walk Training on Plasma Renin and Angiotensin I Levels in Chronic Heart Failure Patients

作　　者：王兵[1] 许顶立[1] 侯玉清[1] 惠海鹏[1] 孟素荣[1] 刘伊丽[1] 

机构地区：[1]中国人民解放军第一军医大学南方医院心内科,广东省广州市510515

出　　处：《中国循环杂志》2002年第4期266-268,共3页Chinese Circulation Journal

摘　　要：目的 :探讨 6分钟步行运动训练对不同程度慢性心力衰竭 (心衰 )患者血浆肾素、血管紧张素Ⅰ (AngⅠ )的影响。方法 :将 6 0例心功能Ⅱ～Ⅲ级的慢性心衰患者随机分为训练组 (n =32 )和对照组 (n =2 8) ,在入院 2 4小时之内做 6分钟步行运动实验 ,记录其行走距离 ,检测血浆肾素和AngⅠ浓度。然后 ,2组均行常规抗心衰药物治疗 ,但训练组每天2次行 6分钟步行运动训练 ,8周后重复检测上述指标。结果 :运动训练显著改善慢性心衰症状 ,训练组步行运动距离在治疗 8周后较对照组更加明显 ,有显著性差异 (P <0 0 5 )。治疗 8周后 ,2组慢性心衰患者血浆肾素、AngⅠ浓度较入院时均明显下降 ,但训练组下降的程度比对照组更显著 (P <0 0 5～ 0 0 1)。结论Objective: To investigate the effect of six-minutes walking training on plasma renin and angiotensin Ⅰ(Ang Ⅰ) levels in chronic heart failure (HF) patients. Methods: Sixty NYHA Ⅱ-Ⅲ HF patients were randomized into two groups, training group (n=32) and control group (n=28). Six-minutes walking test was performed within 24 hours after the patients were admitted. The walking distance, plasma renin and Ang Ⅰ levels were investigated before and after the test. The patients of both groups were treated with routine drugs for heart failure. Six-minutes walking training was only performed in the training group twice a day for 8 weeks. The above parameters were investigated once again at the end of the training. Results: The symptoms were improved and walking distance was extended significantly in HF patients after exercise training. Plasma renin and Ang Ⅰ levels were significantly more reduced in training group than in the control group after 8 week of treatment. Conclusion: Six-minutes walking training could alleviate the excessive activation of reninangiotensin system in HF patient.

关 键 词：运动疗法 六分钟步行运动训练 慢性心力衰竭 患者血浆 肾素 血管紧张素I 

分 类 号：R541.6[医药卫生—心血管疾病]