左旋甲状腺素片个体化治疗在预防多结节性甲状腺肿手术后复发中的作用  

Role of individualized treatment with levothyroxine sodium tablets in the prevention of postoperative recurrence of multiple nodular goiter

作　　者：刘峰 姚晓军 元敏 LIU Feng;YAO Xiao-jun;YUAN Min(Department of Thyroid and Breast Surgery, Shenzhen Longhua District Central Hospital, Shenzhen 518110, China)

机构地区：[1]深圳市龙华区中心医院甲状腺乳腺外科,518110

出　　处：《中国实用医药》2017年第34期91-93,共3页China Practical Medicine

摘　　要：目的研究左旋甲状腺素片个体化治疗在预防多结节性甲状腺肿手术后复发中的作用。方法 180例多结节性甲状腺肿患者,随机分为对照组和实验组,各90例。对照组不服用药物,实验组给予口服左旋甲状腺素片个体化治疗。比较两组的临床效果。结果对照组出现甲状腺结节复发21例,复发率为23.33%,实验组出现甲状腺结节复发4例,复发率为4.44%,两组复发率比较差异具有统计学意义(P<0.05)。实验组患者口服左旋甲状腺素片个体化治疗时间<1年复发率为16.67%,服药时间1~2年复发率为12.00%,服药时间2~3年复发率为4.26%。结论多结节性甲状腺肿术后患者进行左旋甲状腺素片个体化治疗,能够降低结节性甲状腺肿的复发,值得临床应用。Objective To study the effect of individualized treatment with levothyroxine sodium tablets in the prevention of postoperative recurrence of multiple nodular goiter. Methods A total of 180 multiple nodular goiter patients were randomly divided into control group and experimental group, with 90 cases in each group. The control group received no drug, and the experimental group received individualized treatment with oral levothyroxine sodium tablets. The clinical effect in two groups was compared. Results The control group had 21 recurrence cases of thyroid nodules, with recurrence rate as 23.33%, which were 4 cases and 4.44% in the experimental group, and their difference was statistically significant（P〈0.05）. The experimental group had individualized treatment time of oral levothyroxine sodium tablets 〈1 year recurrence rate as 16.67%, medication time 1~2 years recurrence rate as 12.00%, and medication time 2~3 years recurrence rate as 4.26%. Conclusion Individualized treatment time with levothyroxine sodium tablets for multiple nodular goiter patients can reduce the recurrence of nodular goiter, and it is worthy of clinical application.

关 键 词：左旋甲状腺素片 多结节性甲状腺肿 个体化治疗 术后复发 

分 类 号：R653[医药卫生—外科学]