西药治疗老年难治性高血压的临床研究  

Clinical study of Western medicine in the treatment of senile refractory hypertension

作　　者：侯朝阳[1] 

机构地区：[1]沛县人民医院药剂科,221600

出　　处：《中国实用医药》2017年第36期9-11,共3页China Practical Medicine

摘　　要：目的对西药治疗老年难治性高血压的临床效果进行探究。方法 256例老年难治性高血压患者,随机分为对照组与观察组,每组128例。对照组采用安慰剂,口服阿司匹林和卡维地洛配伍螺内酯的方式对患者进行治疗;观察组采用安慰剂,口服阿司匹林和氯沙坦钾片(科素亚)联合吲达帕胺片的方式对患者进行治疗。对两组患者治疗前后的血压变化进行观察,统计两组患者的治疗效果及不良反应情况,并进行对比分析。结果治疗8周后两组收缩压、舒张压均低于本组治疗前,差异均具有统计学意义(P<0.05);治疗8周后观察组收缩压(126.17±14.47)mm Hg(1 mm Hg=0.133 k Pa)、舒张压(88.47±12.39)mm Hg均低于对照组的(137.74±12.29)、(91.89±9.71)mm Hg,差异均具有统计学意义(P<0.05)。观察组患者治疗总有效率为95.31%,高于对照组的78.13%,差异具有统计学意义(P<0.05)。观察组患者头晕发生率为7.03%,恶心、呕吐发生率为2.34%,食欲不振发生率为11.72%,均低于对照组的21.09%、12.50%、32.03%,差异均具有统计学意义(P<0.05)。结论西药治疗老年难治性高血压有一定的疗效,能够有针对性的解决患者的问题,但不同的西药治疗效果也不同,应选取合适的西药治疗方式,帮助患者快速康复。Objective To investigate the clinical effect of Western medicine in the treatment of senile refractory hypertension. Methods A total of 256 senile patients with refractory hypertension as study subjects were randomly divided into control group and observation group, with 128 cases in each group. The control group received placebo and oral aspirin and carvedilol combined with spironolactone, and the observation group received placebo and oral aspirin and losartan potassium tablets （Cozaar） combined with indapamide tablets. The blood pressure changes before and after treatment were observed, and the treatment effect and adverse reactions in two groups was added up for comparative analysis. Results After 8 weeks of treatment, both groups had lower systolic blood pressure and diastolic blood pressure than before treatment, and their difference was statistically significant （P〈0.05）. After 8 weeks of treatment, the observation group had lower systolic blood pressure as （126.17 ± 14.47） mm Hg （1 mm Hg=0.133 kPa） and diastolic blood pressure as （88.47 ± 12.39） mm Hg than （137.74 ± 12.29） and （91.89 ± 9.71） mm Hg in the control group, and their difference was statistically significant （P〈0.05）, The observation group had higher total treatment effective rate as 95.31% than 78.13% in the control group, and the difference was statistically significant （P〈0.05）. The observation group bad incidence of dizziness as 7.03%, incidence of nausea and vomiting as 2.34% and incidence of anorexia as 11.72%, which were lower than 21.09%, 12.50% and 32.03% in the control group, and their difference was statistically significant （P〈O.05）. Conclusion Western medicine shows certain efficacy in treating senile refractory hypertension, and can be targeted to solve the problem of patients, but the effect of different Western medicine treatment is not the same. Appropriate Western medicine should be chosen to help patients recover quickly.

关 键 词：西药治疗 难治性高血压 血压变化 临床效果 老年 

分 类 号：R544.1[医药卫生—心血管疾病]