不同血清肿瘤标志物在抗结核治疗过程中的变化  

The Change of Different Serum Tumor Markers in the Process of Anti-Tuberculosis Treatment

作　　者：何小珊[1] 朱辉超[2] 郭俊华[3] He Xiaoshan;Zhu Huichao;Guo Junhua(Department of Infectious Diseases, Meizhou People＇s Hospital, Meizhou, 514031;Clinical Laboratory, Meizhou People＇s Hospital, Meizhou, 514031;Respiratory Medicine, Meizhou People＇s Hospital, Meizhou, 514031)

机构地区：[1]广东省梅州市人民医院感染科,梅州514031 [2]广东省梅州市人民医院检验科,梅州514031 [3]广东省梅州市人民医院呼吸内科,梅州514031

出　　处：《基因组学与应用生物学》2017年第11期4523-4527,共5页Genomics and Applied Biology

摘　　要：本研究旨在探讨血清肿瘤标志物糖类抗原CA125、CA199、癌胚抗原(CEA)、肿瘤坏死因子(TNF)、唾液酸(SA)水平在继发性肺结核和结核性胸膜炎患者抗结核治疗过程中的变化。选取2013年3月至2015年6月46例活动性肺结核和42例结核性胸膜炎患者在治疗前、治疗2个月和6个月时收集静脉血,采用Centaur XP化学发光免疫分析法检测血清CA125、CA199、CEA、TNF、SA水平,30名健康体检人员作为对照,实验数据进行统计分析。研究结果表明继发性肺结核患者和结核性胸膜炎患者治疗前患者CA125、CA199、CEA、TNF、SA水平与对照组相比差异显著(p<0.01),当治疗后2个月、6个月,各肿瘤标志物水平都不同程度下降,尤其CA125、CA199、TNF、SA水平差异具有统计学意义(p<0.01)。两组患者CA125、CA199、TNF、SA的敏感性和特异性较高,与疾病的诊断相关性更为显著。综上所述,血清CA125、CA199、TNF、SA水平可作为了解结核病患者病情进展和评价疗效的指标。The study aimed to investigate the serum tumor marker compound carbohydrate antigen CA125, CA199 and carcinoembryonic antigen （CEA）, tumor necrosis factor （TNF）, sialic acid （SA） level in the process of anti-tuberculosis treatment in patients with secondary pulmonary tuberculosis and tuberculous pleurisy. From March 2013 to June 2015 a total of 46 cases of active pulmonary tuberculosis and 42 cases of tuberculosis pleurisy patients before treatment, treatment for 2 and 6 months to collect venous blood, the Centaur XP chemiluminescence immune analysis method for determination of serum CAl25, CA199, CEA, TNF, SA levels, 30 healthy persons as control group, the experimental data for statistical analysis. The results of our study indicated secondary pulmonary tuberculosis patients and pulmonary tuberculosis pleurisy were treated with CA125, CA199, CEA, TNF, SA levels compared with the control group compared with significant difference （p〈0.01）. When 2 months, 6 months after treatment, the tumor marker levels have varying degrees of decline, especially CA199, CA125, TNF, SA level differences has statistical significance （p〈0.01）. The sensitivity and specificity of CA125, CA199, TNF, SA were higher in the two groups, and more significant in the diagnosis of the disease. In conclusion, the level of serum CA125, CA199, TNF and SA can be used as an index to understand the progress of the disease and evaluate the curative effect of the patients with tuberculosis.

关 键 词：血清肿瘤标志物 继发性肺结核 结核性胸膜炎 抗结核 

分 类 号：R521[医药卫生—内科学]