ω-3多不饱和脂肪酸对吸烟男性2型糖尿病患者内皮功能影响的研究  

Effect of ω-3 polyunsaturated fatty acid on endothelial function in smoking men with type 2 diabetes mellitus

作　　者：蔡晓盛 杨立善 陶凯 余玉慧 陈景海 陈颖 周乐 

机构地区：[1]浙江省温州市中心医院急诊科/全科医学,浙江温州325000 [2]浙江省苍南县人民医院眼科,浙江苍南325800 [3]浙江省温州市中心医院内分泌科,浙江温州325000 [4]浙江省温州市中心医院超声影像科,浙江温州325000 [5]浙江省温州市中心医院检验科,浙江温州325000

出　　处：《中国现代医生》2017年第36期10-14,共5页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2014KYB255);浙江省温州市公益性社会发展科技项目(Y20170277)

摘　　要：目的探讨ω-3多不饱和脂肪酸(ω-3 PUFA)对吸烟男性2型糖尿病(T2DM)患者内皮功能影响。方法将60例吸烟男性T2DM患者按随机原则分为A、B两组,每组30例。采取2个阶段交叉实验设计,每阶段3个月。第1阶段A组口服ω-3 PUFA片,B组口服安慰剂,两组剂型相同,每天早晚各1片,第1阶段实验开始和结束时间为T1和T2;经1个月药物洗脱期后,第2阶段两组治疗措施互换,B组服用ω-3 PUFA,A组服用安慰剂,第2阶段实验开始和结束时间为T3和T4。于每个阶段开始和结束时间检测患者内皮依赖性血流介导的舒张功能(FMD)、空腹血糖、GHB、TC、LDL-C、HDL、TG、IL-6、纤溶酶原激活物抑制剂-1(PAI-1)。结果第1阶段A组治疗后T2时间FMD较T1时间显著升高,TG、LDL-C、IL-6、PAI-1较T1显著降低,差异有统计学意义(P<0.05)。第2阶段B组治疗后T4时间FMD较T3时间显著升高,TG、LDL-C、IL-6、PAI-1较T3显著降低,差异有统计学意义(P<0.05)。结论ω-3 PUFA可改善吸烟男性T2DM患者内皮功能,对心脑血管预防保护有重要作用。Objective To investigate the effect of ω-3 polyunsaturated fatty acids（ω-3 PUFA） on endothelial function in smoking men with type 2 diabetes mellitus（T2DM）. Methods 60 male smokers with T2DM were randomly divided into A and B groups, with 30 cases in each group. The patients underwent two-stage cross-experimental design, with 3 months in each stage. In the first phase, the group A was given omega-3 PUFA tablets orally, and the group B was given placebo. The dosage in the two groups was the same, with 1 tablet in daily morning and evening. The experiment start and end time in the first stage was T1 and T2. After one month of drug-eluting phase, the treatment measurements in the two groups were reversed in phase 2. The group B received omega-3 PUFA, and the group A received placebo. The experiment start and end time in the second stage was T3 and T4. Patients were monitored for endothelium-dcpendent blood flow-mediated diastolic function （FMD）, fasting plasma glucose, GHB, TC, LDL-C, HDL, TG, IL-6, plasminogen activator inhibition-l（PAI-1） at the beginning and end of each phase. Results In the first stage, FMD in the group A at T2 after treatment was significantly higher than that at T1 after treatment, and the TG, LDL-C, IL-6 and PAI-1 at T2 after treatment were significantly lower than those at T1 after treatment（P〈0.05）. In the second stage, the FMD in group B at T4 after treatment was significantly higher than that at T3 after treatment（P〈0.05）, and the levels of TG, LDL-C, IL-6 and PAI-1 in T3 at T4 after treatment were significantly lower than those at T3, and the difference was significant （P〈0.05）. Conclusion ω-3 PUFA can improve endothelial function in smoking men with T2DM and play an important role in the prevention and protection of cardiovascular and cerebrovascular diseases.

关 键 词：Ω-3多不饱和脂肪酸 2型糖尿病 吸烟 男性 内皮功能 

分 类 号：R587.1[医药卫生—内分泌]