植物来源药物治疗寄生虫病的研究进展  

Plant-derived drugs against parasitic diseases

作　　者：陈静波 吕志跃 CHEN Jing-bo;LU Zhi-yue(Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080;Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080;Ministry of Education Key Laboratory of Control of Tropical Diseases, Sun Yat-sen University, Guangzhou, Guangdong 510080;Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, Guangdong 510080, China)

机构地区：[1]中山大学中山医学院,临床医学专业八年制广东广州510080 [2]中山大学中山医学院寄生虫学教研室,广东广州510080 [3]中山大学热带病防治研究教育部重点实验室,广东广州510080 [4]广东省媒介生物防控工程技术研究中心,广东广州510080

出　　处：《热带医学杂志》2017年第12期1684-1689,共6页Journal of Tropical Medicine

基　　金：国家重点研发计划项目(2016YFC1202003,2016YFC12005000);国家自然科学基金(81371836,81572023,81271855,81261160324);中国科技部国家科学技术资源基础平台项目(TDRC-2017-22);广东省自然科学基金(2014A030313134);广东省科技计划项目(2016A050502008);广州市科技计划项目(201607010029);中央高校基本科研业务费专项资金资助(17ykpy11);中山大学2016年教学改革与课程建设重点课题;国家大学生创新训练项目;广东省大学生创新训练项目;中山大学本科生学生业余科研暨科研助理计划项目

摘　　要：在人类疾病史中,寄生虫病由来已久,且一直是无法根除的重大公共卫生问题。氯喹、吡喹酮、阿苯达唑、甲苯达唑等药物虽杀虫效果较为理想,却存在产生耐药性和毒副作用较大等诸多弊端,而植物来源的药物具有毒副作用小、疗效好等优点,弥补了上述药物的不足。本文就一些常见的人体寄生虫病的植物或植物提取物治疗展开综述,介绍了一些植物药物治疗常见寄生虫病的机制和疗效,为临床上使用植物来源的药物治疗寄生虫病提供参考依据。In the history of human disease, parasitic disease has been existed for a long time, and is a major public health problem that has been unable to eradicate. Although anti-parasite drugs such as chloroquine, praziquantel, albendazole and mebendazole, have ideal effects on killing some parasites, they also have disadvantages like drug resistance and quite strong side-effects. However, plant-derived drugs have advantages like small side-effects and high curative rates. This review summarizes anti-parasite mechanisms and curative effects of plant-derived drugs, which will contribute to the development of novel plant-derived drugs against parasitic diseases.

关 键 词：寄生虫病 植物来源药物 治疗 

分 类 号：R53[医药卫生—内科学] R282.71[医药卫生—临床医学]