HPV分型联合TCT检查在宫颈病变中的临床价值  

Clinical Value of HPV Typing Combined with TCT Examination in Cervical Lesions

作　　者：张旭[1] 蒲琴[1] 王晶 苟艺文 雷蕾 

机构地区：[1]绵阳四0四医院检验科,四川绵阳621000 [2]凉山州第一人民医院检验科,四川西昌615000

出　　处：《四川医学》2017年第12期1410-1413,共4页Sichuan Medical Journal

摘　　要：目的了解绵阳地区女性HPV的感染情况,探讨HPV分型联合TCT检查在女性宫颈病变中的应用价值。方法收集我院2015年1月至2016年6月期间同时进行HPV21分型与TCT检查的2491例患者检测结果,并进行统计分析。结果 2491例患者中,HPV阳性率29.75%,以单一感染为主,主要为HPV16、52、58和53型;21~30岁年龄组HPV阳性率最高,41~50岁年龄组CIN I级以上病变率最高,主要以HPV16、52和58型为主;单一HPV分型检查与HPV分型联合TCT检查预测宫颈病变的灵敏度分别为94.2%、100%,特异性分别为12%、28%,阳性预测值分别为74.71%、79.31%,阴性预测值分别为42.86%、100%,两种方法阳性检出率差异有统计学意义(P<0.05)。结论绵阳地区女性宫颈HPV感染趋于年轻化,以HPV16、52和58型感染为主;HPV分型联合TCT检查可以明显降低宫颈病变筛查的漏诊率,提高特异性。Objective To investigate the prevalence of female HPV infection in Mianyang, and to explore the value of HPV typing combined with TCT in the diagnosis of female cervical lesions. Methods Testing results of 2491 patients who under- went both HPV21 typing and TCT during January 2015 to June 2016 in our hospital,were collected and analyzed. Results Amongthe 2491 patients,the HPV positive rate was 29.75% ,with a majority of single infection,mainly HPV16,52,58 and 53. The HPV positive rate of 21 to 30-year-old age group was highest and the rate of CIN grade I or higher lesion in 41 to 50-year-old age group was highest, mainly HPV16,52 and 58. In the prediction of cervical lesions, the sensitivity of single HPV typing and HPV typing com- bined with TCT were 94. 2% and 100% ,the specificity were 12% and 28% ,the positive predictive value were 74.71% and 79. 31% and the negative predictive value were 42. 86% and 100%, respectively. As for positive detection rates of the two methods,the differ- ence was statistically significant（P 〈 0. 05）. Conclusion The infected female population of HPV at cervical tends to be younger in Mianyang area,with a majority of HPV16,52 and 58 infection. HPV typing combined with TCT examination can significantly reduce the rate of missed diagnosis and improve specificity of cervical lesion screening.

关 键 词：HPV 基因分型 TCT 宫颈病变 

分 类 号：R711[医药卫生—妇产科学]