中国多省份人群IL1B-511C/T和IL1RN+8006T/C单核苷酸多态性与冠心病相关性的Meta分析  

Associations of interleukin gene IL1B-511C/T and IL1RN +8006T/C polymorphisms with coronary artery disease in Chinese population: meta-analysis

作　　者：赵娜[1] 王兴宁[2] 张瑞[2] ZHAO Na;WANG Xingning;ZHANG Rui(Department of Blood Transfusion;Department of Laboratory, Affiliated Hospital of Yan＇an University, Yan＇an 716000, China)

机构地区：[1]延安大学附属医院心脑血管分院输血科,陕西延安716000 [2]延安大学附属医院检验科,陕西延安716000

出　　处：《细胞与分子免疫学杂志》2017年第10期1409-1414,共6页Chinese Journal of Cellular and Molecular Immunology

基　　金：延安市惠民计划(2015HM-06-01)

摘　　要：目的探讨中国多省份人群白细胞介素1β(IL-1β)基因IL1B-511C/T和IL-1受体拮抗剂(IL1RN)基因+8006T/C单核苷酸多态性(SNP)与冠心病(CHD)的相关性。方法通过文献检索收集2017年6月前已发表或完成的与IL1B和IL1RN基因单核苷酸基因多态性与CHD相关性研究的文献,将不符合要求的文献剔除,以漏斗图检验入选文献的偏移性,并根据各入选文献结果的同质性检验结果进行数据合并,计算总比值比(OR)和95%可信区间(CI),Meta分析采用Review Manager 5.3版软件。结果本研究共纳入8篇文献,其中有1460例CHD患者和1547例对照者。Meta分析结果显示IL1B基因IL1B-511C/T位点等位基因模型合并后的OR为1.17,95%CI为[1.04,1.31];隐形基因模型合并后的OR为1.58,95%CI为[1.32,1.90]。IL基因IL1RN+8006T/C基因多态性结果显示等位基因模型合并后的OR为0.55,95%CI为[0.43,0.69],共显性基因模型合并后的OR为0.51,95%CI为[0.40,0.66]。结论 IL1基因IL1B-511C/T和IL1RN+8006T/C基因多态性与CHD易感性存在相关性,前者可增加患CHD的风险,后者可降低患CHD的风险。Objective To explore the relationships between the IL1 B-511 C/T and IL1 RN ＋8006 T/C polymorphisms and coronary heart disease（ CHD） in Chinese population. Methods We analyzed case-control studies regarding the associations of the IL1 B-511 C/T and IL1 RN ＋ 8006 T/C polymorphisms with CHD in Chinese population by searching Pub Med,EMBASE,VIP Database,Wanfang and China National Knowledge Infrastructure databases. All articles were rigorously evaluated and screened based on the inclusion and exclusion criteria. Meta-analysis was performed using Review Manager 5. 3 software. Results Eight case-control studies with a total of 1460 CHD patients and 1547 control subjects met the inclusion criteria. The pooled results from IL1 B-511 C/T polymorphism showed increased risk in al elic model（ OR = 1. 17,95% CI = 1. 04-1. 31）,recessive model（ OR = 1. 58,95% CI = 1. 32-1. 90） and homozygote model（ OR = 1. 38,95% CI =1. 09-1. 74）. But for IL1 RN ＋ 8006 T/C polymorphism,decreased risk was observed in allelic model（ OR = 0. 55,95% CI =0. 43-0. 69）,dominant model（ OR = 0. 52,95% CI = 0. 40-0. 66） and heterozygote model（ OR = 0. 51,95% CI = 0. 40-0. 66）. Conclusion The IL1 RN ＋ 8006 T/C polymorphism may play a protective role in CHD. The IL1 B-511 C/T polymorphism is found to be associated with a significant increased risk for CHD based on our analysis.

关 键 词：白细胞介素基因 冠心病 基因多态性 META分析 

分 类 号：R392.12[医药卫生—免疫学] R541.4[医药卫生—基础医学]