补肾促卵冲剂治疗排卵障碍性不孕“肾虚血瘀”作用机制的研究  

Study on the mechanism of Bushen Culuan Chongji treating "kidney deficiency and blood stasis" in ovulatory dysfunctional infertility

作　　者：马堃[1] 李敏[1] 

机构地区：[1]中国中医科学院,北京100700

出　　处：《中国中药杂志》2017年第23期4445-4450,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81674019)

摘　　要：肾虚血瘀是排卵障碍性不孕的主要原因,肾虚是主要病理机制,血瘀是主要病理表现,是一直贯穿始终的重要因素。"补肾促卵冲剂"在中医理论指导下,继承前辈多年临床经验,结合排卵障碍性不孕的病因病机特点和现代药理研究成果,精选成方,既保持了中医辨证施治和"异病同治"的特色,又体现了"病证结合"的优越性。在"补肾促卵冲剂"治疗排卵障碍性不孕系统研究中,该方无急性毒性反应,未测出LD50。其高、中、低剂量组在生殖遗传毒性和致畸及围产期实验中,均未发现不良反应和毒副作用。在药效学实验中发现,其对大鼠卵泡发育与成熟、黄体形成起到明显促进作用。以"肾虚血瘀"为切入点,对无排卵型异常子宫出血、多囊卵巢综合征、高催乳素血症、未破裂卵泡黄素化综合征、黄体功能不足、卵巢早衰/卵巢储备功能下降6种排卵障碍性不孕的有效性和安全性进行临床观察,验证了其贡献度,体现了"辨病与辨证相结合"的特色,诠释了"异病同治"的治疗原则,为临床提供科学依据。Kidney deficiency and blood stasis is the main cause of ovulatory dysfunctional infertility. Kidney deficiency is the main pathological mechanism. Blood stasis is the main pathological manifestation, and it is an important factor throughout. Bushen Culuan Chongji is under the guidance of traditional Chinese medicine（TCM） theory, previous years of clinical experience, combined with the etiology and pathogenesis of anovulatory infertility and modem pharmacological research results, selected, not only maintains the TCM syndrome differentiation and different diseases features, but also reflects the superiority of the combination of disease. In the study of Bushen Culuan Chongji in the treatment of anovulatory infertility, there was no acute toxicity and no LI^0 was detected. No adverse effects and side effects were found in the reproductive, genetic, toxicity, teratogenic, and perinatal tests in their high and low dose groups. In pharmacodynamics experiments, it can promote the development and maturation of follicles and the formation of corpus lute- um in rats. Taking the kidney deficiency and blood stasis syndrome as the breakthrough point, systematically study the efficacy, safety and mechanism of six ovulatory dysfunctional infertility diseases, including abnormal uterine bleeding-ovulatory disorders, polycystic ovary syndrome, high prolactin, luteinized unruptured follicle syndrome, luteal phase defect and diminished ovarian reserve/premature ovarian failure. It verified the contribution degree of reinforcing kidney and resolving stasis TCM, reflected the characteristics of combi- nation between disease differentiation and syndrome differentiation, interpreted the treatment principles of treating different diseases with the same method, and provided scientific basis for clinical treatment.

关 键 词：异病同治 补肾活血法 肾虚血瘀证 补肾促卵冲剂 排卵障碍性不孕 

分 类 号：R271.14[医药卫生—中医妇科学]