中药清毒胶囊配合HAART 80例老年HIV/AIDS病人的临床观察  

Clinical observation on 80 cases of elderly patients with HIV/AIDS treated by traditional Chinese medicine Qingdu capsule combined with HAART

作　　者：文彬[1] 李秀娟[2] 周小潇[1] 李璇[1] 刘振威[1] 姜枫[1] 张亚萍[1] 邓鑫[1] 

机构地区：[1]广西中医药大学附属瑞康医院,南宁530011 [2]广西中医药大学第一附属医院,南宁530023

出　　处：《中国艾滋病性病》2017年第12期1086-1088,共3页Chinese Journal of Aids & STD

基　　金：国家重大传染病专项(2012ZX10005010-001);国家科技部国际合作项目(2014DFA30580);广西区自然基金(2013GXNSF AA019172);教育部新世纪优秀人才支持计划(NCET-13-0745);广西科技攻关课题(15104003-1-9;14124004-2-2;1355005-1-1);广西教育厅课题(KY2016LX136);广西中医药大学校级课题(2015MS028);广西八桂学者特聘专家团队资助;广西特聘专家团队资助~~

摘　　要：目的探讨清毒胶囊配合高效抗反转录病毒治疗(HAART)对老年艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)客观疗效及生活质量的影响。方法对80例行HAART的老年HIV/AIDS病人随机分为观察组和对照组,对照组仅给HAART治疗,观察组在HAART的同时配合清毒胶囊治疗。对比两组患者治疗前后各时点CD4+T淋巴细胞(简称CD4细胞)计数、病毒载量完全抑制率及生活质量评分。结果治疗3个月时,观察组与对照组CD4细胞计数分别为(388.6±61.2个/μL vs 350.4±59.6个/μL,P<0.05),对照组较基线差异无统计学意义(P>0.05)。治疗6个月时观察组与对照组CD4细胞计数分别为(414.5±62.7个/μL vs 351.4±56.4个/μL,P<0.05),观察组增幅超过60个/μL;病毒载量完全抑制率方面,两组比较差异无统计学意义(P>0.05)。治疗12个月时观察组和对照组患者的CD4细胞计数分别为(415.4±60.3个/μL vs 348.4±57.8个/μL,P<0.05);观察组与对照组病毒载量完全抑制率分别为95.0%vs 80.0%,差异有统计学意义(P<0.05)。比较生存质量总分,观察组各治疗时点均优于对照组(P<0.05)。结论清毒胶囊配合HAART治疗老年HIV/AIDS病人,既可重建免疫功能,保持病毒抑制率,又可提高生活质量及服药依从性。Objective To explore the effect of Qingdu capsule combined with HAART and quality of life in elderly patients with HIV/AIDS.Methods 80 cases elderly patients with HIV/AIDS were divided into observation group and control group.The control group was treated only by HAART,and the observation group treated with HAART and Qingdu capsule.CD4＋T lymphocyte count and viral load were measured before and after the treatment,while the life quality of the patients in the two groups were compared.Results After the treatment for 3 months,the CD4＋T lymphocyte counts in the observation group and the control group were 388.6±61.2 vs 350.4±59.6（P〈0.05）and for 6 months,414.5±62.7 vs351.4±56.4（P〈0.05）respectively,with the observation group rising more than 60 per microliter.There was no significant difference between the two groups in the complete inhibition rate of viral load（P〈0.05）.After the treatment for 12 months,the CD4＋T lymphocyte counts of the two groups were 415.4±60.3 vs348.4±57.8（P〈0.05）and the complete inhibition rate of viral load was（95.0%vs 80.0%）,with the difference statistically significant（P〈0.05）.The observation group had a better quality of life than the control group（P〈0.05）.Conclusion Qingdu capsule combined with HAART can improve the immune function,maintain the virus inhibition rate,and improve the quality of life and medication compliance.

关 键 词：老年艾滋病病人 高效抗反转录病毒治疗 清毒胶囊 CD4+T淋巴细胞计数 病毒载量 生存质量 

分 类 号：R512.91[医药卫生—内科学] R28[医药卫生—临床医学]