扬州市2013-2015年梅毒母婴传播阻断工作临床干预情况  

Clinical intervention of syphilis mother to child transmission in Yangzhou city from 2013-2015

作　　者：戴艳 王红[1] 王静[1] 陈剑[1] 杨春华 万金 

机构地区：[1]扬州大学医学院附属医院扬州市妇幼保健院皮肤科,江苏扬州225002

出　　处：《中国艾滋病性病》2017年第12期1135-1137,共3页Chinese Journal of Aids & STD

摘　　要：目的了解近3年扬州市预防梅毒母婴传播工作的实施情况,探讨临床干预的时机、药物对妊娠结局和先天梅毒的影响,为今后梅毒母婴阻断工作提供科学依据。方法整理2013-2015年扬州市预防梅毒母婴传播的网络数据,对妊娠梅毒及新生儿梅毒案例进行分析。结果 2013-2015年,孕产妇总数114 136人,梅毒阳性人数317人,阳性率0.28%。梅毒孕产妇生产先天梅毒新生儿3人。317名妊娠梅毒患者按孕早期和孕中晚期治疗时间分组,不良妊娠结局分别为1.6%和7.6%(χ~2=7.08,P<0.01);按青霉素类及非青霉素类治疗药物分组,不良妊娠结局分别为2.0%和46.7%(χ~2=72.61,P<0.01);按是否规范治疗分组,不良妊娠结局分别为1.1%和22.2%(χ~2=38.59,P<0.01);三组不良妊娠结局对比,差异均有统计学意义。结论对妊娠期梅毒患者的早期诊断、青霉素规范治疗,可显著改善妊娠结局,减少先天梅毒的发生;妊娠期及新生儿的定期监测随访以及高危儿预防性治疗不可忽视。Objective To know the situation of mother-to-child transmission（MTCT）of syphilis during 2013-2015 in Yangzhou and to explore the proper time for clinical intervention,effects of the drugs on pregnancy outcome and congenital syphilis,so as to provide scientific basis for future MTCT of syphilis.Methods Data of MTCT of syphilis were reviewed,and the cases of pregnant syphilis and neonatal syphilis were analyzed accordingly.ResultsAmong all the number of 114 136 pregnant women during the years,317 cases were infected with pregnant syphilis,and 3 cases with congenital syphilis.317 cases of pregnant syphilis were treated based on the groups of the early and late stages of pregnancy and the adverse pregnancy outcomes were 1.6% and 7.6%（χ-2=7.08,P0.01）.Adverse outcomes were 2.0%and 46.7%（χ-2=72.61,P0.01）based on groups of penicillin and non-penicillin treatment,and 1.1% and 22.2%（χ-2=38.59,P0.01）based on the groups of standard or non-standard treatment.Comparison of the above three outcomes showed differences statistically significant.Conclusion Early diagnosis and standard treatment to pregnant syphilis patients can improve pregnant outcomes significantly and reduce occurrence of congenital syphilis infection.Regular monitoring to pregnant women,follow-up visits to the newborns and prophylactic treatment to the newborns cannot be neglected.

关 键 词：妊娠期梅毒 母婴传播 妊娠结局 预防治疗 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]