丝素蛋白在组织工程中的应用及进展  

Application and Development of Silk Fibroin in Tissue Engineering

作　　者：孙英皓 马大坤 蒋玉东 姜波 王岩松[1] 

机构地区：[1]哈尔滨医科大学附属第二医院骨外科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2017年第34期6794-6797,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81271696)

摘　　要：组织工程是生物支架材料、种子细胞和生物活性因子的有机组合,其中支架材料为种子细胞的黏附载体,为细胞的生长增殖及新陈代谢提供适宜的微环境,并最终被生物体逐渐降解而被再生组织替代。支架材料为周围组织提供机械支持,并引导再生组织按照预定结构和方向生长。同时,各种生物活性物质可以加入支架材料中,比如各种生长因子以及抗体等,扩大了支架材料的应用范围。丝素蛋白具有可控且缓慢的生物降解性,突出的机械性能,良好的生物相容性,支持多种细胞的黏附、生长和分化增殖,已经用于血管、骨、软骨及神经组织等方面的组织工程研究。Tissue engineering is the organic combination of biological scaffold materials, seed cells and bioactive factors. Scaffold materials provide seed cells with a suitable microenvironment, where seed cells can adhere, grow and metabolize, and will be biodegraded eventually and replaced by regenerated tissues. Scaffolds provide mechanical support to the surrounding tissues, and guide regenerated tissues in accordance with a predetermined direction and structure. Meanwhile, scaffolds can contain kinds of bioactive factors, such as growth factors and antibodies, expanding the application in tissue engineering. Silk fibroin with slow and controllable biodegradability, outstanding mechanical properties, and biocompatibility, supports a variety of cell adhesion, growth, differentiation and proliferation. Silk fibroin has been used in blood vessel, bone, cartilage and nervous tissue regeneration in tissue engineering.

关 键 词：丝素蛋白 组织工程 支架材料 

分 类 号：R318.08[医药卫生—生物医学工程]