白念珠菌酵母相-菌丝相形态转换机制的研究进展  

Advances in the Mechanism of Yeast-Hyphae Phenotypic Transitionin Candida Albicans

作　　者：逄金花 唐建国[1] 童译庆 方阳欣 李康馨 

机构地区：[1]复旦大学附属上海市第五人民医院创伤急救危重病医学中心,上海200240

出　　处：《现代生物医学进展》2017年第35期6950-6954,共5页Progress in Modern Biomedicine

基　　金：上海市卫生和计划生育委员会科研课题面上项目(201540136);上海市第五人民医院科研课题项目(2016WYYJ03)

摘　　要：白念珠菌是人体内重要的条件性致病真菌,形态多样性是其重要的生物学特征,不同形态细胞之间可相互转换。酵母相-菌丝相形态转换是白念珠菌中典型形态转换系统,与白念珠菌粘附、侵袭性等方面密切相关。宿主相关环境因素作用于白念珠菌,激活相应的信号传导通路,调控下游应答基因的表达,共同调控白念珠菌菌丝发育。结合目前关于白念珠菌形态转换的研究,认为广泛和深入的信号通路主要有:环磷酸腺苷/蛋白激酶A(c AMP/PKA)信号通路、丝裂原激活蛋白激酶(MAPK)信号通路、Rim101介导的p H信号通路和Tup1介导的负调控信号通路共同调控形态转换。该文将近年来国内外白念珠菌形态转换及其信号传导通路调控机制方面的进展进行综述分析。As an importantopportunistic fungal pathogen, the morphological plasticityis a prominent biological feature of Candida albicans. C. albicans can switch among a number of morphological phenotypes. Yeast-hyphaephenotypic transitionisa typical phenotypic transition system. Phenotypic transition is involved in the adhesion and invasiveness of C. albicans. The host related environmental factors act on Candida albicans, activate the corresponding signaling pathway, regulate the expression of downstream response genes, and regulate the hyphal development of Candida albicans. According to current research on the conversion of Candida albicans morphology, that pathway widely and deeply are： the camp / protein kinase A （cAMP/PKA） signaling pathway, mitogen activated protein kinase （MAPK） signaling pathway, Rim101 mediated pH signaling pathway and Tupl mediated negative regulation of signaling pathways regulating morphological transformation. In this review, we will focus on the development of phenotypic transitions and the regulatory mechanisms of signal transduction pathways in this pathogenic organism.

关 键 词：白念珠菌 形态转换 菌丝相 cAMP/PKA信号通路 MAPK信号通路 

分 类 号：R379.4[医药卫生—病原生物学]