祛风平喘方治疗支气管哮喘临床研究  

Effect of Expelling Rheumatism and Asthma Chinese Medicine Combined with Conventional Therapy on Pulmonary Function and Immune Function in Patients with Bronchial Asthma

作　　者：张立波 邓妍妍 朱建勇[2] 

机构地区：[1]湖北医药学院附属人民医院,湖北十堰442000 [2]十堰市人民医院,湖北十堰442000

出　　处：《中医学报》2017年第12期2331-2335,共5页Acta Chinese Medicine

基　　金：湖北省十堰市太和医院院级课题(2014KF21)

摘　　要：目的:观察祛风平喘方联合常规疗法治疗支气管哮喘患者的临床疗效,并观察其对患者肺功能及免疫功能的影响。方法:120例支气管哮喘患者按数字随机法分为观察组与对照组,各60例。对照组患者给予祛痰止咳、解痉平喘、雾化吸入、抗生素等常规治疗,观察组在对照组治疗基础上给予祛风平喘方。两周后,比较两组患者临床疗效,治疗前后肺功能,咳嗽、喘息等中医证候积分,检测治疗前后外周血嗜酸性粒细胞(eosinophil,EOS)、Ig E水平以及外周血CD3+、CD_4^+、CD8+水平,并计算CD_4^+/CD8+比值。结果:观察组有效率为96.67%,显著高于对照组(88.33%),差异有统计学意义(P<0.05)。两组患者治疗前咳嗽、喘息、肺部体征、胸闷、咽痒、夜间症状/憋醒、舌质、舌苔、脉象等中医证候积分无显著差异(P>0.05);治疗后以上指标均显著降低,且观察组显著低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前Ig E、EOS、CD3+、CD_4^+、CD8+水平、CD_4^+/CD8+无显著差异(P>0.05);治疗后观察组与对照组比较,差异有统计学意义(P<0.05);两组患者治疗后第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、用力肺活量(forced vital capacity,FVC)、FEV1/FVC、呼气峰流速值(peak expiratory flow,PEF)均显著改善,且观察组显著优于对照组(P<0.05)。结论:祛风平喘方治疗支气管哮喘疗效显著,可降低呼吸道症状,减轻气道及肺组织损伤,提高患者免疫功能。Objective： To explore the effect of expelling rheumatism and asthma Chinese Medicine combined with conventional therapy on pulmonary function and immune function in patients with bronchial asthma,to provide a theoretical basis for the treatment of bronchial asthma with combination of TCM and Western medicine. Methods： 120 cases of bronchial asthma patients were randomly divided into the observation group and the control group,each contained 60 cases. The control group was given expectorant,relieving a cough,antispasmodic,relieving asthma,aerosol inhalation,antibiotics and other conventional treatment,the observation group received expelling rheumatism and asthma Chinese Medicine on the basis of treatment of the control group,after two weeks of continuous treatment,curative effect was observed. Clinical curative effect,improvement of pulmonary function of the two groups were compared,cough,wheezing and other TCM symptom scores before and after treatment were compared later,the peripheral blood eosinophils（ EOS）,immunoglobulin E（ Ig E） level and peripheral blood CD＋＋3,CD4~＋,CD8 levels were detected,CD4~＋/CD＋8 ratio were calculated. Results： The total effective rate of the observation group was 96. 67%,significantly higher than that of the control group（ 88. 33%）,there was statistical significance（ P〈0. 05）; The TCM syndrome scores of cough,wheezing pulmonary signs,chest suppression,pharyngeal itching nocturnal symptoms/arousal,tongue nature,coating on the tongue of the two groups before treatment had no significant difference（ P〈0. 05）,the data of the two groups was significantly decreased after the treatment,and the data of the observation group was sharply lower than that of the control group,there was statistical significance（ P〈0. 05）; IgE,EOS,CD＋3,CD4^＋,CD＋8,CD4^＋/CD＋8 levels of the two groups before treatment had no significant difference（ P〈0. 05）,the difference after treatment between the two groups was large,there was statistical significance（

关 键 词：祛风平喘方 支气管哮喘 肺功能 免疫功能 嗜酸性粒细胞 第1秒用力呼气容积 用力肺活量 呼气峰流速值 中西医结合 

分 类 号：R259.622.5[医药卫生—中西医结合]