香菇多糖片联合氟康唑治疗老年口腔念珠菌感染临床研究  

Clinical Study of Mushroom Polysaccharide Tablets Combined with Fluconazole in the Treatment of Oral Candidal Infection in Elderly Patients

作　　者：杨令云[1] 

机构地区：[1]郑州市第一人民医院,河南郑州450000

出　　处：《中医学报》2017年第12期2525-2527,共3页Acta Chinese Medicine

基　　金：河南省中医药科学研究专项课题(2013ZY04022)

摘　　要：目的:观察香菇多糖片联合氟康唑治疗老年口腔念球菌感染的临床疗效。方法:60例口腔念球菌感染患者按照随机数字表法(1∶1)分为观察组和对照组各30例。对照组给予安慰剂与氟康唑治疗,观察组给予香菇多糖片联合氟康唑。两组共治疗4周,4周后观察两组患者的黏膜萎缩、口腔疼痛、红斑症状的变化,评估其临床疗效,观察治疗前后唾液真菌培养的计数。随访2个月,统计复发率。结果:(1)两组患者临床疗效比较:观察组痊愈18例,显效7例,有效2例,无效3例,有效率90.00%;对照组痊愈10例,显效8例,有效3例,无效9例,有效率70.00%;两组有效率比较,差异有统计学意义(P<0.05)。(2)两组患者治疗4周后唾液真菌计数比较,观察组治疗前菌落数/m为176,治疗后菌落数/m为8;对照组治疗前菌落数/m为188,治疗后菌落数/m为98;两组唾液真菌计数比较,差异有统计学意义(P<0.05)。(3)两组患者随访复发率比较:观察组复发5例,复发率27.78%;对照组复发7例,复发率70.00%,两组复发率比较,差异有统计学意义(P<0.05)。结论:香菇多糖片联合氟康唑治疗老年性口腔念球菌疗效显著,复发率低。Objective： To observe the clinical efficacy of Mushroom Polysaccharide tablets combined with fluconazole in the treatment of senile oral cavity streptococcus infection. Methods： 60 cases of oral Candida infection were randomly divided into the observation group and the control group with 30 cases in each group. The control group was given placebo treatment and fluconazole,and the observation group was given Mushroom Polysaccharide tablets combined with fluconazole. The two groups were treated for 4 weeks. After 4 weeks,the mucosal atrophy,oral pain and erythema symptoms were observed in two groups. The clinical efficacy was evaluated,and the count of salivary fungi culture before and after treatment was observed. After 2 months of follow-up,the recurrence rate was statistically analyzed. Results：（1）the clinical efficacy of the two groups were compared： in the observation group,recovered 18 cases,markedly effective in 7 cases,effective in 2 cases,invalid in 3 cases,the effective rate was 90. 00%; in the control group,recovered 10 cases,markedly effective 8 cases,effective 3 cases,invalid 9 cases,the effective rate 70. 00%; and the difference was statistically significant（ P〈0. 05）.（2）As for the fungal colony counts in the saliva of patients in the two groups 4 weeks after treatment,the fungal colony count/m of the observation group before treatment was 176,while that after treatment was8; the fungal colony count/m of the control group before treatment was 188,while that after treatment was 98; the difference from the comparison of their fungal colony counts was of statistical significance（ P〈0. 05）.（3）Two groups of patients were followed up for recurrence rate： in the observation group,relapsed in 5 cases,the recurrence rate was 27. 78%; in the control group,7 cases re-curred,and the recurrence rate was 70. 00%. There was a significant difference between the two groups（ P〈0. 05）. Conclusion：The curative effect of Mushroom Polysaccharide tablets combined with fluconazole in

关 键 词：口腔念珠菌 香菇多糖片 氟康唑 中西医结合 

分 类 号：R276.8[医药卫生—中医五官科学]