刺激响应聚合物在生物医药中的应用  

Stimuli-Responsive Polymers in Biomedical Applications

作　　者：李子程 李攻科[1] 胡玉玲[1] 

机构地区：[1]中山大学化学学院,广州510275

出　　处：《化学进展》2017年第12期1480-1487,共8页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21675178;21475153;21575168);广东省自然科学重点基金项目(No.2015A030311020;2016A030313358);广东省公益研究与能力建设专项基金(No.2015A030401036);广州市民生科技重大专项(No.201604020165)资助~~

摘　　要：刺激响应聚合物是一类能够根据外界环境变化,如p H、离子、温度、光等刺激而改变自身物理化学性质的功能性聚合物。近年来,刺激响应聚合物由于其独特的刺激-响应功能性,在疾病诊断、药物递送、传感器等领域具有广泛的应用。根据不同刺激类型,刺激响应聚合物有不同分类。本文根据化学刺激、物理刺激及生物刺激三方面,综述了刺激响应聚合物的合成方法及其响应机理,并对这类功能材料的应用前景进行了展望。Stimuli-responsive polymers are capable of exhibiting reversible or irreversible changes in physical and/or chemical properties in response to small changes in external environment,such as p H,ions,temperature,light,etc.In recent years,stimuli-responsive polymers have been widely used in disease diagnosis,drug delivery,and sensors.Depending on the type of the external stimuli,stimuli-responsive polymers can be classified into several categories.This article reviews the synthesis methods and the mechanism of the stimuliresponsive polymers based on the chemical stimulation,physical stimulation and biological stimulation.Furthermore,the long-term prospect and the potential applications of these functional materials are introduced.

关 键 词：刺激响应 聚合物 药物递送 传感器 

分 类 号：O631.2[理学—高分子化学]