“肝藏魂”理论与慢性乙型肝炎伴失眠症状患者的相关性  

Correlation between theory of 'liver storing soul' in chronic hepatitis B patients with insomnia

作　　者：张鑫[1] 周振华[1] 李曼[1] 孙学华[1] 高亚婷[1] 高月求[1] 

机构地区：[1]上海中医药大学附属曙光医院肝病科,细胞免疫实验室,上海市中医临床重点实验室,上海201203

出　　处：《中华中医药杂志》2018年第1期89-92,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81473477,No.81473629,No.81403351,No.81503545),国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(No.2012ZX10005004-002),上海市青年科技英才扬帆计划(No.15YF1412300),上海市中医药事业发展三年行动计划项目(No.ZY3-LCPT-1-1001,No.ZY3-CCCX-3-3027)

摘　　要：目的:探讨"肝藏魂"理论与慢性乙型肝炎(CHB)伴失眠症状患者的相关性。方法:对CHB伴失眠症状患者和失眠症患者(各100例)进行中医辨证分型,计算匹兹堡睡眠质量指数量表(PSQI)和中医证候积分并比较两组患者PSQI积分差异,研究不同证型CHB伴失眠症状患者的中医证候积分和PSQI积分的相关性。结果:CHB伴失眠症状患者的睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍积分和PSQI总积分明显高于国内常模和失眠症患者(P<0.01,P<0.05),催眠药物积分高于国内常模(P<0.01)。CHB伴失眠症状患者以肝郁脾虚证和肝肾阴虚证为主,失眠症患者以肝郁化火证和阴虚火旺证为主,且CHB伴失眠症状患者的两个主要证型的PSQI总积分与中医证候积分呈正相关(P<0.01)。结论:与失眠症患者比较,CHB伴失眠症状患者的失眠症状尤为明显;两组患者失眠症状的病机均与"肝藏魂"功能有关。Objective： To explore the correlation between theory of liver storing soul and chronic hepatitis B （CHB） patients with insomnia. Methods： TCM syndromes of CHB patients with insomnia and insomnia patients were analyzed, 100 patients each group, the scores of Pittsburgh sleep quality index （PSQI） and TCM symptoms scores were calculated and the difference of PSQI scores between the two groups was compared to study the correlation between the score of PSQI and TCM Syndrome in different syndrome types of CHB patients with insomnia. Results： The scores of sleep quality, onset time, sleep time, sleep efficiency,sleep disorders scores and PSQI of CHB patients with insomnia were significantly higher than that of the domestic norm and insomnia patient （P〈0.01, P〈0.05）, but the scores of sodium amytal was significantly higher than that of the domestic norm patients （P〈0.01）. The syndrome of stagnation of liver qi and spleen deficiency and syndrome of yin deficiency of liver and kidney were common in CHB patients with insomnia while liver depression transforming into fire and syndrome of hyperactivity of fire due to yin deficiency were common in insomnia patients. The scores of TCM syndrome and PSQI of the two main TCM syndromes of CHB with insomnia were positively correlated （P〈0.01）. Conclusion： Compared with insomnia patients, CHB patients showed more obvious symptoms. The pathogenesis of CHB patients with insomnia and insomnia patients are related to the theory of liver storing soul.

关 键 词：肝藏魂 慢性乙型肝炎 失眠 匹兹堡睡眠质量指数量表 

分 类 号：R256.23[医药卫生—中医内科学] R259[医药卫生—中医学]