疏风解毒胶囊预防急性肺损伤随机临床研究  

Lung injury prevention with Shufeng Jiedu Capsules:A clinical trial of acute lung injury

作　　者：何龙[1] 赵昕[1] 杨秀捷[1] 齐文升[1] 李光熙[1] 蓝海涛[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中华中医药杂志》2018年第1期395-397,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中国中医科学院广安门医院横向研究课题(No.81737)~~

摘　　要：目的:观察疏风解毒胶囊对急性肺损伤的预防作用。方法:前瞻性收集2016年1月至11月肺损伤预测评分>4,中医辨证为毒热或痰热的患者,随机分为对照组和治疗组,对照组采用标准预防策略,治疗组在此基础上加用疏风解毒胶囊口服或鼻饲。收集入院时APACHEⅡ评分、氧合指数、胸部X线或CT检查结果,并观察在院期间发生急性肺损伤数,住院天数以及28d病死率。结果:共收集治疗组50例,对照组49例,两组患者基线情况基本一致,治疗组显著降低急性肺损伤的发生率(P=0.026),经年龄、性别、APACHEⅡ评分等校正后结果差异仍然显著(HR=0.32,P=0.049),但两组患者住院天数和28d病死率无明显差异。结论:疏风解毒胶囊可以显著降低急性肺损伤高危的毒热或痰热患者发生急性肺损伤的风险。Objective： To determine the preventive effect of Shufeng Jiedu Capsules on acute lung injury. Methods： This prospective study collected patients whose lung injury prediction score〉4, and with toxic-heat or phlegm-heat syndrome. The patients were randomly divided into control and treatment group, the control group using standardized prevention strategy, the treatment group combined with Shufeng Jiedu Capsules. APACHE Ⅱ score, oxygenation index, chest X-ray or CT examination were collected at the time of hospital admission and the development of acute lung injury during the hospital stay, hospital length of stay and 28 days mortality were collected either. Results： The development of acute lung injury was significantly reduced in the treatment group （P=0.026）, and the difference was still significant （HR=0.32, P=0.049） after adjusted by age, sex, APACHE H score. There was no significant difference in hospital length of stay and 28 days mortality between the two groups. Conclusion： The use of Shufeng Jiedu Capsules can significantly reduce the development of acute lung injury in patients with high risk and toxic-heat or phlegm-heat syndrome.

关 键 词：疏风解毒胶囊 急性肺损伤 预防作用 毒热证 痰热证 

分 类 号：R259[医药卫生—中西医结合]