血清γ-谷氨酰转移酶与高血压的相关性研究  

Study on correlation between serumγ-glutamyltransferase and hypertension

作　　者：刘莹[1] 刘学奎[2] 杨瑞华[3] 

机构地区：[1]江苏省徐州市中心医院彩超室,221009 [2]江苏省徐州市中心医院中心实验室,221009 [3]江苏省徐州市中心医院心功能科,221009

出　　处：《重庆医学》2018年第1期49-51,共3页Chongqing medicine

摘　　要：目的探讨人群中血清γ-谷氨酰转移酶(γ-GGT)和高血压发病的相关性。方法选取2006年在该院体检的1 487名未患有高血压疾病的人群为研究对象,按照γ-GGT水平分成两组,经过5年的随访,观察2011年高血压的发病情况。检测研究对象的血清谷氨酸氨基转移酶、天冬氨酸氨基转移酶、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖等指标和人体测量学结果。结果 5年的随访观察发现,高γ-GGT组的高血压发病率高于低γ-GGT组,差异有统计学意义(P<0.05)。校正性别和基线各代谢指标后,γ-GGT变化值与高血压的发病率存在相关性[RR=1.012,95%CI(1.004,1.019)],校正性别和各代谢指标5年的变化值后,γ-GGT变化值引起高血压发病的RR=1.013,95%CI(1.005,1.020),差异有统计学意义(P<0.05)。结论γ-GGT与高血压发病密切相关。Objective To investigate the correlation between serum γ-glutamyltransferase（γ-GGT） and hypertension onset. Methods A total of 1 487 subjects without hypertension undergoing physical examination in the hospital during 2016 were selected as the study subjects and equally divided into 2 groups according to γ-GGT level. The hypertension onset situation in 2011 was observed after 5-year follow up. The levels of serum γ-GGT, AST, triacylglycerol, total cholesterol, high density lipoprotein cholesterol （HDL-C）,low density lipoprotein cholesterol（LDL-C）, fasting blood glucose and anthropometry indexes were measured in the study subjects. Results The 5-year follow up found that the incidence rate of hypertension in the high γ-GGT group was higher than that in the IowT-GGT group,the difference was statistically significant（P〈0.05）. After correcting various metabolic indexes of sex and base line, the γ-GGT change value had a correlation with the hypertension incidence rate[RR = 1. 012,95% CI（1. 004, 1. 019）], after correcting the 5-year change value of sex and various metabolic indexes, RR of γ-GGT change value causing hyper- tension onset =1. 013,95%CI（1. 005,1. 020） ,the difference was statistically significant（P〈0.05）. Conclusion γ-GGT is closely correlated with prehypertension.

关 键 词：Γ-谷氨酰转移酶 高血压 随访研究 

分 类 号：R544.1[医药卫生—心血管疾病]