基于稳定同位素的代谢组学临床研究进展  

Stable Isotope Tracer-Based Metabolomics and Applications for Clinical Research

作　　者：高英慧[1] 冯一丹[1] 唐智言 马艳[2] 张学梅[2] 段薇[1] 

机构地区：[1]大连大学附属中山医院内分泌科,中国辽宁大连116001 [2]大连大学医学院,中国辽宁大连116622

出　　处：《生命科学研究》2017年第6期558-564,共7页Life Science Research

基　　金："十二五"国家科技支撑计划项目(2012BAK25B00)

摘　　要：基于稳定同位素示踪的代谢组学不仅能检测疾病发生发展及治疗过程中相关代谢物的变化,还可以对生物体系的代谢物进行定量分析并描述代谢特性。目前,稳定同位素示踪的代谢组学技术可在受试者体内直接追踪到代谢网络的单个原子,更有利于发现与疾病病因和诊断及药物疗效评估相关的生物标志物。现就稳定同位素示踪代谢组学在临床研究中的应用做简要概述,以期为将来更好地开展代谢组学在临床方面的研究提供重要依据。Not only can stable isotope tracer-based metabolomics detect the alteration of metabolites during the development and treatment of diseases, but also quantitatively analyze metabolites and describe the metabolic characteristics of biological system. Recent advances in stable isotope tracer-based metabolomics approaches enable unambiguous tracking of individual atoms through compartmentalized metabolic networks directly in human subjects, therefore it’s a tool to find important biomarkers for identifying etiology of diseases, diagnosing diseases and therapeutic evaluation of medicines. Herein, a brief overview of applications of stable isotope tracer-metabolomics in clinical research was performed with the aim of offering a significant basis for better clinical development of metabolomics.

关 键 词：代谢组学 稳定同位素示踪 生物标志物 临床研究 

分 类 号：Q503[生物学—生物化学] R587[医药卫生—内分泌]