羚玳息风丸联合西药治疗脑外伤后综合征的效果  

Effect of Lingdai Xifeng Pills Combined with Western Medicine in the Treatment of Syndrome Following Traumatic Brain Injury

作　　者：韩毅[1] 刘涌[2] 贾子会 

机构地区：[1]石家庄市中医院ICU,河北石家庄050051 [2]石家庄市中医院麻醉科,河北石家庄050051 [3]高碑店市医院内分泌科,河北保定074000

出　　处：《贵州医科大学学报》2017年第12期1447-1450,共4页Journal of Guizhou Medical University

基　　金：河北省中医药管理局科研项目(2014213)

摘　　要：目的:观察羚玳息风丸联合西药治疗脑外伤后综合征(PTS)的临床效果。方法:将100例颅脑外伤后综合征(PTS)患者均分为对照组(给予茴拉西坦胶囊和尼莫地平口服)和治疗组(在对照组基础上加用羚玳息风丸口服),观察两组患者治疗15 d时的疗效;比较治疗前和治疗15 d时,两组患者MCA、ACA、PCA、BA及VA等颅内动脉平均血流速度,全血黏度、血浆黏度、纤维蛋白原含量、红细胞(RBC)变形指数及RBC压积等血液流变学指标的改变。结果:经过一个疗程(15 d)的治疗,治疗组患者的总有效率显著高于对照组(P<0.05);治疗前两组患者全血黏度、血浆黏度、纤维蛋白原含量、RBC变形指数及RBC压积,大脑颅内动脉MCA、ACA、PCA、VA及BA平均血流速度比较,差异无统计学意义(P>0.05);与治疗前比较,治疗后治疗组患者全血黏度、血浆黏度、纤维蛋白原含量、RBC变形指数及RBC压积显著降低,大脑颅内动脉MCA、ACA、PCA、VA及BA平均血流速度升高,对照组仅全血黏度和RBC变形指数显著降低,PCA显著升高(P<0.05);治疗后,与对照组患者比较,治疗组患者的血浆黏度、纤维蛋白原含量及RBC压积降低更明显,大脑颅内动脉MCA、ACA、VA及BA平均血流速度升高更明显(P<0.05)。结论:羚玳息风丸联合传统西药治疗PTS的效果优于单一传统西药治疗,其机制可能与加用羚玳息风丸后可改善患者血液流变学和颅内血流速度有关。Objective： To observe the clinical efficacy of Lingdai Xifeng pills combine with western medicine in the treatment of syndrome following traumatic brain injury（ PTS）. Methods： A total of100 patients with headache induced by traumatic brain injury were divided into treatment group and control group. Control group were treated with Aniracetam Capsules and nimodipin. Treatment group were treated further with Lingdai Xifeng pills. Compare the clinical efficacy of two groups after 15 d.The changes of average blood flow speed,whole blood viscosity,plasma viscosity,fibrinogen concentration,deformation index and RBC HCT in MCA,ACA,PCA,VA and BA were detected. Results：The total effectiveness of treatment group was significantly higher than control group（ P〈0. 05）. Before treatment,comparison of whole blood viscosity,plasma viscosity,fibrinogen concentration,deformation index and RBC HCT of both groups showed no statistical significance（ P〈0. 05）; compared with before treatment,whole blood viscosity,plasma viscosity,fibrinogen concentration,deformation index and RBC HCT of after treatment were significantly reduced; average blood speed of intracranial cerebral artery MCA,ACA,PCA,VA and BA were increased,and whole blood viscosity and deformation index were significantly reduced in control group,PCA significantly increased（ P〈0. 05）. After treatment,the changes of plasma viscosity,fibrinogen concentration and RBC HCT in treatment group were significantly reduced than that of control group,intracranial cerebral artery（ P〈0. 05）. Conclusion： The Lingdai Xifeng pills combined with western medicine effectively improved the clinical efficacy,its mechanism might be resulted from the Lingdai Xifeng pills improvement on hemorheology index and intracranial cerebral blood flow velocity.

关 键 词：脑外伤后综合征 脑血流 血流动力学 羚玳息风丸 全血黏度 联合用药 

分 类 号：R641[医药卫生—外科学] R651.1[医药卫生—临床医学]