老年慢性心力衰竭患者的血清铁蛋白、铁调素水平变化及临床意义  

Changes of serum ferritin and hepidin in elderly patients with chronic heart failure and their clinical significance

作　　者：付平[1] 柳达[2] 位艳伟 李诗洋[2] 罗文利[2] 

机构地区：[1]石河子大学医学院第一附属医院老年病学,832008 [2]石河子大学医学院第一附属医院老年干部保健二科,832008

出　　处：《实用医学杂志》2017年第24期4122-4125,共4页The Journal of Practical Medicine

基　　金：新疆生产建设兵团农八师师市计划项目(编号:2015YL09)

摘　　要：目的探讨血清铁蛋白(SF)、血清铁调素(Hepc)在老年慢性心力衰竭(CHF)患者中的水平变化及临床意义。方法选择2015年10月至2017年2月老年慢性心力衰竭患者80例作为心衰组,同期住院无心功能不全患者80例作为对照组。检测两组血清铁蛋白(SF)、Hepc水平并进行比较和分析。结果老年心衰组的SF、Hepc、hs-CRP分别为(69.58±27.16)ng/mL、(97.16±16.81)ng/mL、(3.35±1.64)mg/L,对照组的SF、Hepc、hs-CRP分别为(128.46±33.28)ng/mL、(54.12±15.76)ng/mL、(2.80±1.36)mg/L,差异有统计学意义(均P<0.05)。慢性心力衰竭多因素Logistic回归分析,血清铁蛋白为慢性心力衰竭的保护因素(P<0.05),Hepc、超敏C反应蛋白为慢性心力衰竭的独立危险因素(P<0.05)。结论 SF可能是老年慢性心力衰竭的保护因素;Hepc及超敏C反应蛋白可能是老年慢性心力衰竭的危险因素。通过检测SF、Hepc、hs-CRP可早期识别老年慢性心力衰竭,有助于早期预防和治疗老年慢性心力衰竭。Objective To investigate the correlation of serum（SF）and hepcidin（Hepc）level with cardi-ac function and chronic heart failure（CHF）.Methods A total of 80 elderly patients with CHF who had received treatment in our hospital from October 2015 to February 2017 were assigned to CHF group and 80 patients without heart failure were assigned to a control group. Serum SF and hepidin levels in both the groups were measured and compared.Results Serum hepidin and hs-C-reactive protein levels were all significantly higher in CHF group than in the control group[（69.58 ± 27.16）ng/ml vs.（128.46 ± 33.28）ng/mL;（97.16 ± 16.81）ng/mL vs.（54.12 ± 15.76）ng/mL;（3.3 ± 1.64）mg/L vs.（2.78 ± 1.36）mg/L].Multiple logistic regression analysis showed that SF was an independent protective factor for CHF（P 〈 0.05）;Hepc and hs-CRP were independent risk factors for CHF （P〈0.05）.Conclusions Serum hepcidin and hs-C-reactive protein may be risk factors for chronic heart failure. Measurement of serum hepidin and hs-CRP levels is helpful for early prevention and treatment of heart failure.

关 键 词：老年人 慢性心力衰竭 血清铁蛋白 血清铁调素 超敏C反应蛋白 

分 类 号：R541.6[医药卫生—心血管疾病]