环孢素A滴眼液联合氯替泼诺滴眼液治疗春季角结膜炎的疗效  

Efficacy of cyclosporine A eye drops combined with loteprednol eye drops in treatment of vernal keratoconjunctivitis

作　　者：尚庆丽[1] 王鑫[1] 马红蕾[1] 徐曼 

机构地区：[1]河北医科大学第二医院眼科,石家庄050000

出　　处：《中国新药杂志》2017年第24期2960-2963,共4页Chinese Journal of New Drugs

摘　　要：目的:观察环孢素A滴眼液对春季角结膜炎相关临床症状的疗效。方法:将60例春季角结膜炎患者随机分为试验组和对照组,每组30例,对照组患者给予氯替泼诺滴眼液治疗(剂量为每次1滴,tid,疗程为12周);试验组患者给予环孢素A滴眼液(剂量为每次1滴,qid,疗程为12周)及氯替泼诺滴眼液(剂量为每次1滴,tid,疗程为12周)联合治疗。评估患者开始治疗后4周、8周及12周的治疗效果。并按照症状及体征进行疗效评分。结果:试验组和对照组在治疗4周后总体评分均有减低,两组差异有统计学意义(P<0.05),治疗8周、12周后两组总体评分也均有减低,但差异无统计学意义(P>0.05,P>0.05)。结论:局部应用环孢素A滴眼液治疗顽固性春季角结膜炎安全有效,应鼓励局部应用环孢素A与糖皮质激素的联合使用治疗春季角结膜炎,防止并发症的产生。Objective： To investigate the clinical efficacy of cyclosporine A eye drops combined with loteprednol eye drops for treating vernal keratoconjunctivitis. Methods： Sixty vernal keratoconjunctivitis patients were randomly divided into test group （n = 30） to receive cyclosporine A eye drops （qid, one droplet once） combined with loteprednol eye drops （rid, one droplet once） and control group （n = 30） to receive loteprednol eye drops only （rid, one droplet once）. The treatment course was 12 weeks. The efficacy was evaluated at week 4, 8 and 12, respectively, based on clinical symptoms and vital signs. Results： The total scores of the test group and control group both showed decrease at week 4, with statistically significant difference （ P 〈 0. 05 ）. Despite decrease existed in the scores of both groups at week 8 and 12, there was no statistical difference （P 〉0.05 ,P 〉 0.05）. Conclusions： Local administration of cyclosporine A is effective for treating vernal keratoconjunctivitis. cyclosporine A may be topically used in combination with to prevent the occurrence of complications. glucocorticosteroids for treating vernal keratoconjnnctivitis .

关 键 词：春季角结膜炎 环孢素A 氯替泼诺滴眼液 疗效 

分 类 号：R969.4[医药卫生—药理学] R988.1[医药卫生—药学]