不同程度肝损伤患者红细胞分布宽度与凝血酶原时间的差异  

Differences of erythrocyte distribution width and prothrombin time in patients with different degrees of liver injury

作　　者：李月[1] 代震宇[2] 黄佳佳 余爽[1] 

机构地区：[1]重庆医科大学附属第二医院检验科,400010 [2]重庆市中医院骨科,400021

出　　处：《重庆医学》2017年第36期5074-5075,5080,共3页Chongqing medicine

基　　金：重庆市卫生局项目资助(2012-2-60)

摘　　要：目的探讨不同程度肝损伤患者红细胞分布宽度(RDW)与凝血酶原时间(PT)的变化趋势及其临床意义。方法选取重庆医科大学附属第二医院2014年1月至2015年6月住院乙型肝炎患者100例(乙肝组),乙型肝炎肝硬化患者100例(肝硬化组),乙型肝炎病毒相关的原发性肝细胞癌患者50例(肝癌组),以及同期健康体检者100例(对照组)。采用Sysmex XE-2100全自动血细胞分析仪检测所有受试者外周血RDW与红细胞平均体积(MCV),采用Stago Rack Evolutio全自动凝血仪检测PT,并进行比较分析。结果除肝硬化组与肝癌组RDW比较,差异无统计学意义(P=0.099),其余各组间比较差异均有统计学意义(P<0.01),随着病情加重,RDW逐渐变宽;各组间MCV比较,差异无统计学意义(P>0.05);除乙肝组与肝硬化组PT比较,差异无统计学意义(P=0.234),其余各组间比较差异均有统计学意义(P<0.01),随着病情加重,PT逐渐延长。结论RDW、PT的增加与肝损伤的严重程度相关,RDW可能成为预测患者肝损伤程度的指标。Objective To investigate the change trend of erythrocyte distribution width（RDW）and prothrombin time（PT）in patients with different degrees of hepatic injury and its clinical significance.Methods A total of 100 inpatients with hepatitis B（HB group）,100 patients with liver cirrhosis（cirrhosis group）and 50 patients with primary hepatocellular carcinoma（HCC）associated with HBV（liver cancer group）in the Second Affiliated Hospital of Chongqing Medical University from January 2014 to June2015 were selected.The peripheral blood RDW and the average volume of erythrocytes（MCV）of all the subjects were detected by Sysmex XE-2100 automatic hematology analyzer.The PT was measured by Stago Rack Evolutio automatic coagulation analyzer and compared.Results There was no significant difference in RDW between the cirrhosis group and the HCC group（P=0.099）,and the difference between the other groups was statistically significant（P0.01）.As the disease progressed,the RDW gradually increased.There was no significant difference in MCV comparison among all groups（P0.05）.There was no significant difference in PT between the HB group and the cirrhosis group（P=0.234）,and the difference between the other groups was statistically significant（P0.01）.As the disease progressed,PT gradually increased.Conclusion The increase of RDW and PT are related to the severity of liver injury.RDW may be an index to predict the degree of liver injury in patients.

关 键 词：乙型 肝硬化 癌 肝细胞 红细胞分布宽度 凝血酶原时间 红细胞平均体积 

分 类 号：R512.62[医药卫生—内科学] R575[医药卫生—临床医学] R735.7