复方半边莲注射液对阿霉素肾病大鼠模型的药理学作用研究  

Pharmacological Effects of Compound Injection of Lobelia chinensis in Rats with Adriamycin-induced Nephropathy

作　　者：孙嘉婧 刘勇[1] 马岩[2] 马伟[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]哈尔滨商业大学管理学院,黑龙江哈尔滨150028

出　　处：《中医药信息》2018年第1期42-46,共5页Information on Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金项目(No.H201474);黑龙江省博士后基金项目(No.BSH201301);黑龙江中医药大学"优秀创新人才支持计划"青年项目(No.2012001)

摘　　要：目的:研究复方半边莲注射液对阿霉素肾病大鼠模型的相关药效学作用。方法:通过尾静脉一次性注射阿霉素构造48只SD雄性大鼠肾病模型,随机分为空白组、模型组、阳性组和复方半边莲注射液低、中、高剂量组。对其进行尿液及血清的采集,并对相关指标进行分析。结果:高剂量组能显著降低尿液中尿蛋白含量,血液中血肌酐、尿素氮、总胆固醇、甘油三酯、总蛋白、血清蛋白与模型组相比均有明显改善,低、中剂量组相对效果不显著。结论:该复方注射液对有病理学改变的阿霉素肾病大鼠模型,在适宜药物剂量时,具有明确的治疗效果,为后续其在临床应用研究提供了理论基础。Objective: To study the pharmacological effects of compound of Lobelia chinensis injection in Rats with Adriamycin-induced nephropathy. Methods: 48 SD rats were divided into the blank control group,the model group,the positive drug group,and the compound injection groups of Lobelia chinensis( low-dose,medium-dose,high-dose). The models were established by one-time tail vein injection with Adriamycin. Urine and serum were collected for relative analysis. Results: The contents of urinary protein,serum creatinine,blood urea nitrogen,total cholesterol,triglyceride,total protein,and serum albumin were significantly decreased in the compound injection group of Lobelia chinensis with high-dose,compared to the model group;however,the low-dose and medium-dose did not have obvious effect. Conclusion: The compound injection of Lobelia chinensis with high-dose has a significant effect on Adriamycin-induced nephropathy rats,which provides the reference for its further study on its clinical application.

关 键 词：阿霉素肾病 复方半边莲注射液 尾静脉注射 

分 类 号：R285.6[医药卫生—中药学]