Real-time measurement of nano-particle size using differential optical phase detection  

作　　者：李晴 黄河 林峯 吴兴坤 

机构地区：[1]State Key Laboratory of Modern Optical Instrumentation, Department of Optical Engineering, Zhejiang University [2]School of Computer Engineering, Nanyang Technological University

出　　处：《Chinese Optics Letters》2017年第12期15-19,共5页中国光学快报（英文版）

基　　金：supported in part by the National Natural Science Foundation of China(NSFC)under Grant No.61378086

摘　　要：We demonstrate a size sensing technique for nano-particles using optical differential phase measurement by a dual fiber interferometer through phase-generated carrier （PGC） demodulation. Nano-particle diameters are obtained from the differential phase shift as a result of adding an optical scattering perturbation into two-beam interference. Polystyrene nano-particles with diameters from 200 to 900 nm in a microfluidic channel are de- tected using this technique to acquire real-time particle diameters. Compared with amplitude sensing with over i0 mW of laser irradiance, particle sizing by PGC phase sensing can be achieved at a laser power as low as 1.18 mW. We further analyze major sources of noise in order to improve the limits of detection. This sensing technique may find a broad range of applications from the real-time selection of biological cell samples to rare cell detection in blood samples for early cancer screening.We demonstrate a size sensing technique for nano-particles using optical differential phase measurement by a dual fiber interferometer through phase-generated carrier （PGC） demodulation. Nano-particle diameters are obtained from the differential phase shift as a result of adding an optical scattering perturbation into two-beam interference. Polystyrene nano-particles with diameters from 200 to 900 nm in a microfluidic channel are de- tected using this technique to acquire real-time particle diameters. Compared with amplitude sensing with over i0 mW of laser irradiance, particle sizing by PGC phase sensing can be achieved at a laser power as low as 1.18 mW. We further analyze major sources of noise in order to improve the limits of detection. This sensing technique may find a broad range of applications from the real-time selection of biological cell samples to rare cell detection in blood samples for early cancer screening.

关 键 词：DIAMETERS INTERFEROMETER PERTURBATION DEMODULATION screening adding normalized wastewater MUNICIPAL SIZING 

分 类 号：O657.3[理学—分析化学] TB383.1[理学—化学]